Intermediate compositions, and in particular gels and suspensions for foam compositions, are described that include adapalene and benzoyl peroxide in combination. Also described

The present invention concerns a method of treating preadolescent acne, which comprises administering an effective amount of a pharmaceutical composition comprising a fixed combination of adapalene and benzol peroxide to a preadolescent patient in need thereof. According to the invention, the preadolescent patient is from age 7 to age 11, and the pharmaceutical composition comprises from 0.01% to 2% by weight of adapalene and from 0.1 to 5% by weight by weight of benzol peroxide. The present inv...

Intermediate compositions and in particular gels and suspensions for foam compositions are described that include adapalene and benzoyl peroxide in combination. Also described; is the dermatological use of such compositions.

The invention relates to a method for producing an adapalene aqueous gel which method comprises preparing a gelling medium A by mixing water and propylene glycol and adding a gelling agent; preparing an adapalene medium B by dispersing adapalene in water in the presence of a surfactant; adding the adapalene medium B to the gelling medium A; and adjusting the pH to about 4.7-5.3.

FIELD: medicine pharmaceutics.SUBSTANCE: present invention refers to pharmaceutical and medicine and concerns a topical pharmaceutical formulation including in the form of gel containing effective amounts of (a) polymer microspheres containing adapalene of average size 1-100 mcm and (b) clindamycin as well as a method of treating acne with the above formulations are storage-stable at temperature approximately 40°C and relative air humidity approximately 75% for at least 3 months.EFFECT: developi...

FIELD: chemistry.SUBSTANCE: invention relates to chemistry of adamantane derivatives and specifically to a method of producing 2-(adamantyl-1)-4-bromophenol, which is an intermediate product in the synthesis of adapalene - 6-[3-(adamantyl-1)-4-methoxyphenyl]-2- naphthoic acid, which is widely used in dermatology as an effective anti-acne agent. The method of producing 2-(adamantyl-1)-4-bromophenol involves reacting 4-bromophenol with 1-adamantanol and 1-bromoadamantane in molar ratio of 2:1:0.1,...

An aqueous gel composition of the present invention comprising about 0.1 to 0.3 wt % adapalene and about 2.5 to 5.0 wt % benzoyl peroxide as active ingredients wherein both the active ingredients are stabilized in hydrophilic gelling matrix of pH dependent gelling agent comprising crosslinked acrylic acid-based polymer(s).