The invention comprises pyridoxine derivatives of general formula wherein R1 and R2 are identical or different and are methyl ethyl or propyl or together with the carbon atom to which they are attached represent a benzylidene or cyclohexylidene group and salts thereof and their preparation by treating pyridoxine or a salt thereof with a carbonyl compound of the type R1R2CO under dehydrating conditions e.g. in the presence of concentrated sulphuric acid and if desired treating the product with a...

2 - Methyl - 3 - hydroxy - 4 : 5 - bis (hydroxymethyl)-pyridine (pyridoxine) is obtained by treating a substance of the general formula wherein X stands for -NH2 or a group capable of conversion into NH2 by reduction Y stands for hydrogen or halogen and R stands for an alkyl radical such that the carbalkoxy group -COOR is capable of conversion into -CH2OH by reduction with lithium aluminium hydride with lithium aluminium hydride so as to carry out the conversions of the substituents X- CN- and ...

A multi-vitamin preparation containing essential vitamins including calcium pantothenate is stabilized with respect to the calcium pantothenate by the addition of dibasic magnesium phosphate talc or skimmed milk powder. Essential vitamins are A and D thiamin hydrochloride ascorbic acid pantothenic acid and its salts riboflavin pyridoxine hydrochloride and niacin or niacinamide. Examples are given of (a) soft gelatine capsules containing the stabilized multi-vitamin preparation mixed with corn o...

Stabilized solutions are prepared by dissolving thiamine mononitrate or a vitamin B complex containing thiamine mononitrate riboflavin pyridoxine hydrochloride and niacinamide in water or aqueous chlorobutanol and adjusting the pH of the solution to about 3.5 to 4.5 by the addition of a water-soluble non-toxic inorganic acid e.g. hydrochloric sulphuric or nitric acid.ALSOStabilized solutions for parenteral administration are prepared by dissolving thiamine mononitrate or a vitamin B complex cont...

A soluble form of riboflavin is produced by heating it with urea urethane acetamide or nicotinamide until fused an acidic salt being optionally added before or after heating; the proportions are preferably equimolecular and the product may or may not be a definite chemical compound. In the examples (1) riboflavin is fused with urea and monosodium phosphate cooled and dissolved in water; (2) riboflavin is fused with nicotinamide cooled and dissolved in water containing thiamine hydrochloride and...

Physiologically active amino compounds related to pyridoxine are manufactured by heating pyridoxine or an ester thereof with ammonia or ammonium carbonate preferably to at least 100 DEG C. and advantageously in the presence of a solvent for the reactants e.g. methanol or ethanol (with or without up to about 50 per cent of water) water alone (less satisfactorily) or dioxane. The reaction mixture may be worked up by neutralization or evaporation to dryness or by treatment with picric acid to pre...

Physiologically active aldehyde derivatives of pyridoxine of the general formula (wherein R1 represents hydroxymethyl or etherified hydroxymethyl) are manufactured by treating a compound of the general formula (wherein R1 is as above and R represents methyl hydroxymethyl or etherified hydroxymethyl) with an oxidizing agent which is a more highly oxidized compound of chromium or manganese the oxidation being so controlled or limited that the said aldehyde compound is the major product of the re...