The present invention relates to a novel process for the synthesis of Nebivolol product represented in Scheme (1) comprised of a reduced number of high-yield steps and characterized by the kinetic resolution of the two epoxide pairs diastereoisomeric therebetween (mixture 1) allowing to avoid complex chromatographic separations.

A pharmaceutical composition of levamlodipine or a pharmaceutically acceptable salt thereof and a .beta. receptor blocking agent and a use thereof are provided. An active ingredient of the pharmaceutical composition contains levamlodipine or a pharmaceutically acceptable salt thereof and a .beta. receptor blocking agent in which the .beta. receptor blocking agent is one selected from nebivolol bisoprolol betaxolol celiprolol and nadolol. A use of the pharmaceutical composition in preparation of ...

The present invention relates to a process for preparing Nebivolol and more particularly to an improved process for synthesizing enantiomerically enriched 6-fluoro chroman alcohol or epoxide derivatives of formula wherein R and X is defined in the description; as useful intermediates in the preparation of Nebivolol.

The present invention is directed to pharmaceutical compositions comprising nebivolol. More particularly, the present invention is directed to oral pharmaceutical compositions comprising nebivolol hydrochloride having a specific surface area of less than 22103 cm2/g, and process for preparing the same.

The present invention is directed to pharmaceutical compositions comprising nebivolol. More particularly the present invention is directed to oral pharmaceutical compositions comprising nebivolol hydrochloride having a specific surface area of less than 22�103 cm2/g and process for preparing the same.

The present invention relates to a process for the preparation of Nebivolol and more particularly to an improved method of synthesizing 6-fluoro chroman epoxides of formula (I) key intermediates in preparing nebivolol.