The present invention relates to an improved process for preparing simvastatin and more particularly, the improved process for preparing simvastatin expressed by formula 1 with high yield and high purity by performing the following sequential processes comprising: (i) hydrolysis of lovastatin as starting material with potassium t-butoxide in an organic solvent and small amount of water under a mild reaction condition, followed by lactonization of the obtained solid intermediate with preventing f...

The present invention relates to an improved process for preparing simvastatin and more particularly, the improved process for preparing simvastatin expressed by formula 1 with high yield and high purity by performing the following sequential processes comprising: (i) hydrolysis of lovastatin as starting material with potassium t-butoxide in an organic solvent and small amount of water under a mild reaction condition, followed by lactonization of the obtained solid intermediate with preventing f...

The present invention relates to an improved process for preparing simvastat in and more particularly, the improved process for preparing simvastatin expressed by formula 1 with high yield and high purity by performing the following sequential processes comprising: (i) hydrolysis of lovastatin as starting material with potassium t-butoxide in an organic solvent and small amount of water under a mild reaction condition, followed by lactonization o f the obtained solid intermediate with preventing...

1,249,399. Anti-inflammatory compositions. SYNTEX CORP. 21 March, 1969 [22 April, 1968], No. 15093/69. Heading A5B. [Also in Division C2] Anti-inflammatory compositions for topical use comprise steroids of the formula (wherein each of A and B is H or C 1-8 alkyl, or A and B together are tetra- or penta-methylene