The invention relates to a method for manufacturing a polyoxyethylene alkyl ether acetic acid including feeding oxygen into a liquid phase containing polyoxyethylene ether having a hydrocarbon group at the end (hereinafter it may also be referred to as a polyoxyethylene alkyl ether) and water and dehydrogenating and oxidizing the polyoxyethylene alkyl ether in the presence of a platinum catalyst in which the mass ratio between the total mass of the polyoxyethylene alkyl ether and the polyoxyethy...

The present invention provides indane acetic acid and their derivatives and methods for the treating and/or preventing of Alzheimer's diseases.

The present invention provides a compound of formula I;

The present invention provides a mixed crystalline form VIII of agomelatine its method of preparation application and pharmaceutical composition. The said mixed crystal consists mainly of crystalline form VI of agomelatine. The said mixed crystalline form is stable and has good reproducibility. Through stability tests it has been found to be superior to the crystalline form VI in terms of stability. As a result the crystalline form VIII of the present invention possesses advantages in pharmaceut...

The present invention provides the preparation method for (S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)carbamate (formula X compound), the preparation methods for its intermediates (S)-1-(3-methoxyphenyl)-N,N-dimethyl-N-((S)-1-phenylethyl)ethanaminium(formula VI compound), (S)-1-(3-hydroxyphenyl)-N,N-dimethyl-N-((S)-1-phenylethyl)ethanaminium(formula VIII compound) and (S)-1-(3-(ethyl(methyl)carbamoyloxy)phenyl)-N,N-dimethyl-N-((S)-1-phenylethyl)ethanaminium (formula IX compound), as well a...