1,249,661. Antibiotic-sulphonamide compositions. BRISTOL-MYERS CO. 10 Dec., 1968 [15 Dec., 1967], No. 58643/68. Heading A5B. Pharmaceutical compositions in forms suitable for oral, rectal, parenteral and topical administration comprise ampicillin or hetacillin (0.1 to 0.5 parts) and sulphisoxazole (1 part by weight).

1,237,228. Mannich bases of [alpha]-6-deoxy-5-oxy tetracycline. CHAS. PFIZER & CO. Inc. 23 Dec., 1968 [25 March, 1968], No. 61206/68. Heading C2A. Mannich bases of [alpha]-deoxy-5-oxytetracycline having the formula wherein R is amino, #-carhoxyalkylamino, #- amino- #-carboxyalkylamino, #-carboxamidoalkylamino, # - amino - # - carboxamidoalkylamino, or NR 1 R 2 wherein R 1 is C 1-17 alkyl, benzyl, phenethyl, cyclohexyl, C 2-4 hydroxyalkyl, #-aminoalkyl, #-alkylaminoalkyl or #- dialkylaminoalkyl (...

Sparingly soluble salts of streptomycin antibiotics with acyl-embonic acids the acyl being derived from a 2-5C aliphatic acid, are used as antitubercular depot cpds. which obviate frequent i.m. injections and ensure even serum levels. The acetyl-embonates of streptomycin and dihydrostreptomycin are preferred. - In the process the streptomycin as water-sol. salt or a complex is reacted in known manner with an acylembonic acid as water-sol. salt or as DMF adduct. Good yields are obtained.

1,178,358. [alpha] - 6 - Deoxy - 5 - oxytetracycline derivatives. CHAS. PFIZER & CO., Inc. 17 June, 1968 [25 March, 1968], No. 28838/68. Heading C2A. The invention comprises 2-amido-N-(pyrrolidinomethyl) - [alpha] - 6 - deoxy - 5 - oxytetracycline, 2 - amido - N - (morpholinomethyl) - [alpha]- 6-deoxy-5- oxytetracycline, and their pharmaceutically acceptable acid addition salts. The compounds are prepared by reacting [alpha]-6-deoxy- 5-oxytetracycline with an equimolecular amount of formaldehyde...

An analgesic preparation for application to the oral mucosa (including the gingival and lip surfaces) comprises an aqueous or hydroalcoholic gel and a water-soluble salicylate compound dissolved in said gel, said preparation having a pH of from 4 to 7. Generally, the preparation has a salicylate ion concentration of 2 to 10% by weight. Salicylate compounds specified are choline, potassium, sodium, calcium and morpholine salicylates. The gelling agent for the preparation may be methyl cellulose, ...

An antiperspirant deodorant composition comprises Neomycin, an astringent aluminium compound and a fabric corrosion inhibitor. The Neomycin may be in the form of the components Neomycins B and C or its salts or salts of its components e.g. Neomycin sulphate and Neomycin hydrochloride. Specified astringent aluminium compounds are aluminium chlorhydroxide, aluminium chlorhydroxide ethylate complex, sodium aluminium chlorhydroxy lactate, aluminium chloride, aluminium sulphamate, and aluminium pheno...

A penicillin preparation for incorporation with fodder is prepared by suspending a sparingly water-soluble penicillin compound in an aqueous solution of a hydrophilic colloidal digestible organic substance and drying the solution by dispersion into preheated air either directly or upon a carrier kept in whirling suspension in a drying chamber by an upward stream of preheated air. Specified colloids are glue, gelatine, hydrolized starch, water-soluble cellulose dervatives, pectin, agar, gums and ...

The invention comprises coumarin derivatives of the general formula where R1 is an alkyl radical of not more than three carbon atoms and the manufacture of these derivatives by condensing an alkali metal derivative of an aralkyl malonic ester of the formula where R2 represents an alkyl group of not more than three carbon atoms with an acetyl-salicylic halide (preferably the chloride) to give a product of the formula treating...