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269414
条记录, 当前第10/26942页。
公开号
公开日
申请号
申请日
1.
US2014080787A1
2014/3/20
US201314026667
2013/9/13
专利标题
:Method for the Treatment of Neuropathies Associated with Charcot-Marie-Tooth 1A (CMT1A) Disease
专利权人
:
NAT INST OF HEALTH US DEPT OF HEALTH AND HUMAN SERVICES [US]
;
CHARCOT MARIE TOOTH ASS [US]
;
The present invention relates to compositions and methods for the treatment, prevention, and diagnosis of neuropathies due to PMP22 mis-expression in a subject having Charcot-Marie-Tooth disease, especially Charcot-Marie-Tooth 1A disease. The present invention incorporates the use of small molecule proteasome inhibitors such as, but not limited to, Bortezomib to inhibit or reduce the overexpression of the PMP2 gene.
2.
WO2014041324A1
2014/3/20
WO2013GB00380
2013/9/11
专利标题
:PROCESS FOR PREPARING OF BORTEZAMIB
专利权人
:
CIPLA LTD [IN]
;
KING LAWRENCE LOUIS [GB]
;
The present invention provides improved processes for the preparation of Bortezomib, tert-butyl[1-({(1S)-3-methyl-1-[(3aS,4S,6S,7aS)-3a,5,5-trimethylhexahydro-4,6-methano-1,3,2-benzodioxaborol-2-yl]butyl}amino)-1-oxo-3-phenylpropan-2-yl]carbamate of formula (IV) and N-{(1S)-3-methyl-1-[(3aS,4S,6S,7aS)-3a,5,5-trimethylhexahydro-4,6- methano-1,3,2-benzodioxaborol-2-yl]butyl} phenylalanine of formula (V). Compound (IV) is prepared by coupling (1R)-3-methyl-1-[(3aS,4S,6S,7aR)-3a,5,5-trimethyl- hexah...
3.
AU2012322797A1
2014/3/20
AU20120322797
2012/10/11
专利标题
:Uses for and article of manufacture including HER2 dimerization inhibitor pertuzumab
专利权人
:
GENENTECH INC
;
The present application describes uses for and articles of manufacture including Pertuzumab, a first-in-class HER2 dimerization inhibitor. In particular, the application describes methods for extending progression free survival in a HER2-positive breast cancer patient population
4.
US2014079788A1
2014/3/20
US201313783122
2013/3/1
专利标题
:METHODS OF TREATMENT OF PANCREATIC CANCER
专利权人
:
ABRAXIS BIOSCIENCE LLC [US]
;
ABRAXIS BIOSCIENCE LLC [US]
;
The present invention provides methods and compositions for treating pancreatic cancer in an individual who has been previously treated for pancreatic cancer (e.g., gemcitabine-based therapy) by administering a composition comprising nanoparticles that comprise a taxane and an albumin. The invention also provides combination therapy methods of treating pancreatic cancer (for example, in an individual who has been previously treated for pancreatic cancer) comprising administering to an individual...
5.
US2014079665A1
2014/3/20
US201214118007
2012/5/15
专利标题
:THERAPEUTIC ANTI-IGF1R COMBINATIONS
专利权人
:
MERCK SHARP & DOHME [US]
;
The present invention provides, in part, compositions including an anti-IGF1R antibody or antigen-binding fragment thereof and any one or more of cisplatin, pemetrexed, gemcitabine and/or irinotecan
6.
US2014080848A1
2014/3/20
US201314026545
2013/9/13
专利标题
:ARYL AMINE SUBSTITUTED PYRIMIDINE AND QUINAZOLINE AND THEIR USE AS ANTICANER DRUGS
专利权人
:
UNIV NAT TAIWAN [TW]
;
UNIV NAT YANG MING [TW]
;
A series of mono- and di-substituted quinazoline and pyrimidine derivatives based on the skeleton of erlotinib (an EGFR inhibitor) were synthesized and their bioactivities against hepatocellular carcinoma and human lung adenocarcinoma were evaluated.
7.
WO2014041551A1
2014/3/20
WO2012IN00614
2012/9/14
专利标题
:FORMULATION COMPRISING IMATINIB AS ORAL SOLUTION
专利权人
:
NATCO PHARMA LTD [IN]
;
PARVATANENI DURGA MAHESWARI [IN]
;
SOMA DEEPTHI [IN]
;
APPADWEDULA VENKATA SATYA NARAYANA [IN]
;
ADIBHATLA KALI SATYA BHUJANGA RAO [IN]
;
NANNAPANENI VENKAIAH CHOWDARY [IN]
;
A pharmaceutical solution suitable for oral administration containing an effective amount of Imatinib including its pharmaceutically acceptable salts and polymorphs such as [alpha], [beta] or [alpha]2 to improve the dosage uniformity, palatability and thus patient compliance. The invention also relates to a process for the preparation of stable aqueous oral formulation that can be swallowed easily and comprising active ingredient in an effective concentration for the better therapy especially fo...
8.
AU2012301042A1
2014/3/20
AU20120301042
2012/8/24
专利标题
:Transdermal therapeutic system for 5-aminolevulinic acid hydrochloride
专利权人
:
LOHMANN THERAPIE SYST LTS
;
The invention relates to a transdermal therapeutic system, comprising a back layer that is impermeable to an active ingredient, a polymer matrix containing the active ingredient, and a protective layer that can be pulled off, wherein 5-aminolevulinic acid hydrochloride is used as the active ingredient and the basic polymer of the polymer matrix is an adhesive polyacrylate. Said transdermal therapeutic system is suitable for diagnosing and treating preliminary stages of skin cancer, such as actin...
9.
US2014080818A1
2014/3/20
US201313855592
2013/4/2
专利标题
:TWO-COMPONENT PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF PAIN
专利权人
:
APPLIED PHARMACY SERVICES INC [US]
;
APPLIED PHARMACY SERVICES INC [US]
;
The present invention is directed to a pharmaceutical composition that includes a combination of about 2-5 milligrams of a non-steroidal anti-inflammatory drug and from about 2-30 milligrams of an opioid analgesic in a single pharmaceutical dosage unit that can provide effective chronic pain management with the added benefit of reduced side effects such as withdrawal and gastrointestinal disorders. The non-steroidal anti-inflammatory drug may be piroxicam and the opioid analgesic may be buprenor...
10.
AU2012314661A1
2014/3/20
AU20120314661
2012/9/21
专利标题
:Formulations based on solid dispersions
专利权人
:
ABBVIE DEUTSCHLAND
;
The present invention relates to formulations comprising a solid dispersion product of an active agent having at least one of a hydrogen bond donor moiety (e.g. ibuprofen, fenofibric acid or naproxen) and a proton donor moiety and a pharmaceutically acceptable polyvinyllactam polyvinylacetate poly(alkylene glycol) graft copolymer, and to methods for preparing such formulations.
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