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269414
条记录, 当前第8/26942页。
公开号
公开日
申请号
申请日
1.
US8680276B2
2014/3/25
US13/056458
2010/3/4
专利标题
:Synthesis of (4as,7as)-octahydro-1h-pyrrolo[3,4-b]pyridine
专利权人
:
The present invention relates to the stereoselective synthesis of (4aS7aS)-octahydro-1H-pyrrolo[34-b]pyridine as well as the conversion thereof to give Moxifloxacin. Particularly the present invention relates to a method for the synthesis of (4aS7aS)-octahydro-1H-pyrrolo[34-b]pyridine of formula (I) comprising: (a) the optical resolution by enzymatic hydrolysis of the intermediate dialkyl-1-alkylcarbonylpiperidine-23-dicarboxylate racemate of formula (II) to give following isolation the intermed...
2.
US8680097B2
2014/3/25
专利标题
:Benzothiophene alkanol piperazine derivatives and their use as antidepressant
专利权人
:
Cspc Zhongqi Pharmaceutical Technology (shijiazhuang) Co. Ltd.
;
The invention discloses benzothiophene alkanol piperazine derivatives and their use as antidepressants. The invention discloses the said benzothiophene alkanol piperazine derivative having triple inhibition effect on the reuptake of 5-HT NA and DA. Compared with clinical used antidepressants so far having single target e.g. desipramine and fluoxetine and clinical used antidepressants so far having double targets e.g venlafaxine and duloxetine the said benzothiophene alkanol piperazine derivative...
3.
US8679507B2
2014/3/25
专利标题
:Testosterone olfaction
专利权人
:
A composition of an olfactory stimulus mechanism for stimulating the production of testosterone. A method of increasing the level of testosterone in an individual by smelling the truffle extract causing androgens in the truffle extract to attach to the olfactory bulb in the individual and inducing testosterone production. A method of preventing the onset of Alzheimer's disease in an individual by the individual smelling the truffle extract and inducing testosterone production in the individual. ...
4.
US8680297B2
2014/3/25
专利标题
:Manufacturing process for tiotropium bromide
专利权人
:
Drug Process Licensing Assoc., Llc
;
The present invention relates to a novel manufacturing process of pharmaceutically active compound of formula I used as a long-acting anticholinergic bronchodilator. Starting from oxalic acid derivative of formula III the invention describes preparation of a novel cyclic anhydride of formula II which is very efficient precursor in the synthesis of Tiotropium bromide (compound of formula I).
5.
US8680317B2
2014/3/25
US12/699024
2010/2/2
专利标题
:Processes for making ethyl acetate from acetic acid
专利权人
:
Celanese International Corporation
;
A process for hydrogenating acetic acid to form of ethyl acetate and mixtures of ethyl acetate and ethanol. The hydrogenation is done in the presence of catalyst preferably on a support that optionally includes a support modifier.
6.
US8680321B2
2014/3/25
US12/699003
2010/2/2
专利标题
:Processes for making ethanol from acetic acid using bimetallic catalysts
专利权人
:
Celanese International Corporation
;
A process for selective formation of ethanol and/or ethyl acetate from acetic acid by hydrogenating acetic acid in the presence of a Pt/Sn catalyst or a Re/Pd catalyst. The catalyst may further comprise a support modifier to improve selectivity for the desired product.
7.
US8680342B2
2014/3/25
US13/094610
2011/4/26
专利标题
:Process for recovering alcohol produced by hydrogenating an acetic acid feed stream comprising water
专利权人
:
Celanese International Corporation
;
Purifying and/or recovery of ethanol from a crude ethanol product obtained from the hydrogenation of acetic acid from an feed stream comprising water. The presence of water does not significantly impact acid conversion or selectivity to ethanol. Further the addition of water allows for improved recovery of ethanol.
8.
US8680070B2
2014/3/25
US13/475067
2012/5/18
专利标题
:Medical implants containing adenosine receptor agonists and methods for inhibitiing medical implant loosening
专利权人
:
NEW YORK UNIVERSITY
;
The invention provides methods and compositions for reducing or inhibiting bone resorption osteoclast differentiation and stimulation and the loosening of medical prostheses by administering a compound or agent that modulates an adenosine receptor such as the adenosine A2A receptor in particular an agonist of an adenosine A2A receptor. The invention also extends to pharmaceutical compositions comprising such an agent that modulates an adenosine receptor such as an adenosine A2A agonist and to pr...
9.
US8679544B2
2014/3/25
US13/750869
2013/1/25
专利标题
:Formulation of diclofenac
专利权人
:
Iceutica Pty Ltd.
;
The present invention relates to methods for producing particles of diclofenac using dry milling processes as well as compositions comprising diclofenac medicaments produced using diclofenac in particulate form and/or compositions and to methods of treatment of an animal including man using a therapeutically effective amount of diclofenac administered by way of said medicaments.
10.
WO2014042392A1
2014/3/20
WO2013KR08083
2013/9/6
专利标题
:COMPOSITION USING METFORMIN FOR PREVENTING OR TREATING IMMUNE DISEASES INCLUDING LUPUS
专利权人
:
CATHOLIC UNIV IND ACAD COOP [KR]
;
The present invention relates to a composition for preventing or treating immune diseases through the suppression of B cell activity induced by metformin. More particularly, the present invention relates to a composition comprising a metformin compound or a pharmaceutically acceptable salt thereof as an active ingredient for preventing or treating immune diseases, wherein the composition is characterized by the suppression or reduction of B cell activity which is a cause of disease. The present ...
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