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269414
条记录, 当前第1/26942页。
公开号
公开日
申请号
申请日
1.
US20140086980A1
2014/3/27
US13/977461
2011/12/29
专利标题
:Treatment of erectile dysfunction and other indications
专利权人
:
Strategic Science & Technologies, Llc
;
The present invention generally relates to the transdermal delivery of various compounds. In some aspects transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising a phosphodiesterase type 5 inhibitor and/or a salt thereof and optionally a hostile biophysical environment and/or a nitric oxide donor. In some cases the composition may be stabilized using a combination of a stabilization pol...
2.
US20140088034A1
2014/3/27
US14/115170
2012/5/10
专利标题
:Nitric oxide/cgmp pathway inhibition of vla-4 related cell adhesion
专利权人
:
The invention provides methods of treating nitric oxide/cGMP pathway-cell adhesion disorders and related pharmaceutical compositions diagnostics screening techniques and kits. In one embodiment the invention relates to a method for down-regulating ?4?1-integrin affinity and inhibiting and reversing adhesion formation in patients or subjects in need using a nitric oxide donor.
3.
US20140088127A1
2014/3/27
US13/625110
2012/9/24
专利标题
:Novel process to prepare pioglitazone via several novel intermediates
专利权人
:
Cadila Healthcare Limited
;
A novel process for preparing thiazolidinediones preferably Pioglitazone as described. Also described are novel intermediates involved in its synthesis and process for their preparation and use in medicine.
4.
US20140088135A1
2014/3/27
US13/846804
2013/3/18
专利标题
:Immunosuppressive macrolide powder for oral suspension
专利权人
:
The present invention describes pharmaceutical compositions that comprise a tacrolimus powder for oral suspension that exhibits great stability as a powder for suspension and also once prepared as the extemporaneous suspension without the formation of cake-like clusters same having a satisfactory flavour and a pleasant aroma. The invention also describes the method for preparing the pharmaceutical compositions same being a dry method that comprises mixing tacrolimus and presieved pharmaceuticall...
5.
US20140086975A1
2014/3/27
US13/879440
2010/10/21
专利标题
:Hydrogel formulation for dermal and ocular delivery
专利权人
:
Rutgers, The State University Of New Jersey
;
Formulations of cross-linkable polymers capable of forming non-toxic and biocompatible hydrogels in situ containing at least one of doxycycline or minocycline. Methods of using the hydrogels for treating the skin or ocular tissues of mammals exposed to vesicant compounds such as sulfur mustard (SM) nitrogen mustard (NM) or half mustard (2-chloroethyl ethyl sulfide (CEES)) are also disclosed.
6.
US20140088192A1
2014/3/27
US13/992105
2011/12/12
专利标题
:Subcutaneously infusible levodopa prodrug compositions and methods of infusion
专利权人
:
Synagile Corporation
;
The invention features methods compositions and infusion pumps for infusing levodopa prodrugs (e.g. levodopa esters levodopa amides levodopa carboxamides and levodopa sulfonamides) for the treatment of Parkinson's disease.
7.
WO2014045046A2
2014/3/27
WO2013GB52464
2013/9/20
专利标题
:DRUG SUBSTANCE PREPARATIONS, PHARMACEUTICAL COMPOSITIONS AND DOSAGE FORMS COMPRISING S-(+)-FLURBIPROFEN
专利权人
:
AESICA PHARMACEUTICALS LTD [GB]
;
There is described (S)-(+)-2-(2-fluoro-4-biphenylyl) propionic acid, or a salt or ester thereof, having substantially limited amounts of specific impurities associated with the synthesis and purification of the (S)-(+)-2-(2-fluoro-4-biphenylyl) propionic acid.
8.
US2014088165A1
2014/3/27
US201314093956
2013/12/2
专利标题
:Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors
专利权人
:
IWAKI YUKI [JP]
;
KAWANAMI TOSHIO [US]
;
KSANDER GARY MICHAEL [US]
;
MOJI MUNETO [US]
;
NOVARTIS AG [CH]
;
The present invention provides a compound of formula I
9.
US2014088022A1
2014/3/27
US201314028222
2013/9/16
专利标题
:Novel Solid Materials of and Methods for Obtaining Them
专利权人
:
MERCK PATENT GMBH [DE]
;
The instant invention relates to novel solid materials of {[(2S,5R,8S,11S)-5-benzyl-11-(3-guanidino-propyl)-8-isopropyl-7-methyl-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentaaza-cyclopentadec-2-yl]-acetic acid}, methods for producing them, and the use of said solid materials in pharmaceuticals.
10.
US2014086910A1
2014/3/27
US201314013801
2013/8/29
专利标题
:METHODS OF TREATING OR PREVENTING ALZHEIMER'S DISEASE USING INDANE ACETIC ACID DERIVATIVES
专利权人
:
DARA BIOSCIENCES INC [US]
;
The present invention provides indane acetic acid and their derivatives and methods for the treating and/or preventing of Alzheimer's diseases.
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