The present invention relates to the stereoselective synthesis of (4aS7aS)-octahydro-1H-pyrrolo[34-b]pyridine as well as the conversion thereof to give Moxifloxacin. Particularly the present invention relates to a method for the synthesis of (4aS7aS)-octahydro-1H-pyrrolo[34-b]pyridine of formula (I) comprising: (a) the optical resolution by enzymatic hydrolysis of the intermediate dialkyl-1-alkylcarbonylpiperidine-23-dicarboxylate racemate of formula (II) to give following isolation the intermed...

The invention discloses benzothiophene alkanol piperazine derivatives and their use as antidepressants. The invention discloses the said benzothiophene alkanol piperazine derivative having triple inhibition effect on the reuptake of 5-HT NA and DA. Compared with clinical used antidepressants so far having single target e.g. desipramine and fluoxetine and clinical used antidepressants so far having double targets e.g venlafaxine and duloxetine the said benzothiophene alkanol piperazine derivative...

A composition of an olfactory stimulus mechanism for stimulating the production of testosterone. A method of increasing the level of testosterone in an individual by smelling the truffle extract causing androgens in the truffle extract to attach to the olfactory bulb in the individual and inducing testosterone production. A method of preventing the onset of Alzheimer's disease in an individual by the individual smelling the truffle extract and inducing testosterone production in the individual. ...

The present invention relates to a novel manufacturing process of pharmaceutically active compound of formula I used as a long-acting anticholinergic bronchodilator. Starting from oxalic acid derivative of formula III the invention describes preparation of a novel cyclic anhydride of formula II which is very efficient precursor in the synthesis of Tiotropium bromide (compound of formula I).

A process for hydrogenating acetic acid to form of ethyl acetate and mixtures of ethyl acetate and ethanol. The hydrogenation is done in the presence of catalyst preferably on a support that optionally includes a support modifier.

A process for selective formation of ethanol and/or ethyl acetate from acetic acid by hydrogenating acetic acid in the presence of a Pt/Sn catalyst or a Re/Pd catalyst. The catalyst may further comprise a support modifier to improve selectivity for the desired product.

Purifying and/or recovery of ethanol from a crude ethanol product obtained from the hydrogenation of acetic acid from an feed stream comprising water. The presence of water does not significantly impact acid conversion or selectivity to ethanol. Further the addition of water allows for improved recovery of ethanol.

The invention provides methods and compositions for reducing or inhibiting bone resorption osteoclast differentiation and stimulation and the loosening of medical prostheses by administering a compound or agent that modulates an adenosine receptor such as the adenosine A2A receptor in particular an agonist of an adenosine A2A receptor. The invention also extends to pharmaceutical compositions comprising such an agent that modulates an adenosine receptor such as an adenosine A2A agonist and to pr...

The present invention relates to methods for producing particles of diclofenac using dry milling processes as well as compositions comprising diclofenac medicaments produced using diclofenac in particulate form and/or compositions and to methods of treatment of an animal including man using a therapeutically effective amount of diclofenac administered by way of said medicaments.

The present invention relates to a composition for preventing or treating immune diseases through the suppression of B cell activity induced by metformin. More particularly, the present invention relates to a composition comprising a metformin compound or a pharmaceutically acceptable salt thereof as an active ingredient for preventing or treating immune diseases, wherein the composition is characterized by the suppression or reduction of B cell activity which is a cause of disease. The present ...