专利详细信息
专利号 | CN102725288A |
专利标题 | Method for manufacturing a 6-substituted-1-methyl-1H-benzimidazole derivative, and manufacturing intermediate from said method |
专利权人 | DAIICHI SANKYO CO LTD; |
发明人 | YUTAKA IKEUCHI;CHIHARU SATOH;EIJI NUMAGAMI;SATORU NIHEI;HISAKI KAJINO; |
申请号 | CN2010853605 |
申请日 | 2010/11/25 |
公开日 | 2012/10/10 |
优先权号 | |
IPC | C07D417/12; A61K31/427; A61P3/10; A61P29/00; A61P35/00; A61P43/00; C07C213/02; C07C217/90; C07D277/20; C07D277/34; |
专利类型 | |
法律状态查询 | 查看法律状态 |
It is intended to provide a novel method for manufacturing a 6-substituted 1-methyl-1H-benzimidazole derivative and an intermediate of said methods. [Solution] A method for manufacturing a 6-substituted 1-methyl-1H-benzimidazole derivative represented by the following general formula (IV) [wherein R 3 represents a hydrogen atom or a C 1 -C 4 alkyl group], comprising manufacturing a 4-substituted N 2 -methylbenzene-1,2-diamine derivative from a particular 5-substituted N-methyl-2-nitroaniline derivative, subsequently reacting the resulting compound with {4-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]phenoxy}acetic acid or an acid chloride or a mixed acid anhydride thereof, and subsequently subjecting the resulting compound to intramolecular dehydration condensation.
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