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专利详细信息
专利号
CN102725288A
专利标题 Method for manufacturing a 6-substituted-1-methyl-1H-benzimidazole derivative, and manufacturing intermediate from said method
专利权人 DAIICHI SANKYO CO LTD;
发明人 YUTAKA IKEUCHI;CHIHARU SATOH;EIJI NUMAGAMI;SATORU NIHEI;HISAKI KAJINO;
申请号 CN2010853605
申请日 2010/11/25
公开日 2012/10/10
优先权号
IPC C07D417/12; A61K31/427; A61P3/10; A61P29/00; A61P35/00; A61P43/00; C07C213/02; C07C217/90; C07D277/20; C07D277/34;
专利类型
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It is intended to provide a novel method for manufacturing a 6-substituted 1-methyl-1H-benzimidazole derivative and an intermediate of said methods. [Solution] A method for manufacturing a 6-substituted 1-methyl-1H-benzimidazole derivative represented by the following general formula (IV) [wherein R 3 represents a hydrogen atom or a C 1 -C 4 alkyl group], comprising manufacturing a 4-substituted N 2 -methylbenzene-1,2-diamine derivative from a particular 5-substituted N-methyl-2-nitroaniline derivative, subsequently reacting the resulting compound with {4-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]phenoxy}acetic acid or an acid chloride or a mixed acid anhydride thereof, and subsequently subjecting the resulting compound to intramolecular dehydration condensation.
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