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专利详细信息
专利号
WO2014006120A1
专利标题 New positive allosteric modulators of nicotinic acetylcholine receptor
专利权人 H. Lundbeck A/s;
发明人 Eskildsen, Joergen;Sams, Anette Graven;Pueschl, Ask;
申请号
申请日
公开日 2014/1/9
优先权号
IPC C07D40512000;
专利类型
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The present invention relates to compounds according to formula (I) wherein R1 R2 R3 R4 and R5 are H; R6 is selected from methyl and hydroxymethyl; A7 is C-R7 A8 is N and A9 is C-R9; R7 R10 and R11 are H; R9 is OR12 wherein R12 represents a monocyclic saturated ring moiety having 4-6 ring atoms wherein one of said ring atoms is O and the rest is C; and pharmaceutically acceptable salts thereof useful in therapy to compositions comprising said compounds and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine a7 receptor.
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