专利详细信息
专利号 | US8258315B2 |
专利标题 | Process for forming amorphous atorvastatin |
专利权人 | Pfizer Inc.; |
发明人 | Debettencourt, Iii Antone J;Rose, Peter R;Shalaev, Evgenyi;Quallich, George J;Ziegler, Jr Carl B; |
申请号 | US13/079376 |
申请日 | 2011/4/4 |
公开日 | 2012/9/4 |
优先权号 | |
IPC | C07D20700000; |
专利类型 | |
法律状态查询 | 查看法律状态 |
A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin.
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