The present invention provides a kind of Chinese medicine preparation for treating depression. The medicine preparation is prepared with epimedium and anemarrhena rhizome as chief medicine material and ginseng as adjuvant, which are extracted with water or ethanol to obtain the effective components. The medicine is prepared into capsule, tablet, granule and other preparation forms. The cooperation of the three medicine materials can invigorate vital energy and Yin, nourish the heart and invigorate spleen vital energy to cure depression. Experiment shows that the medicine has specific inhibiting effect on several kinds of depression model, can raise the 5-hydroxy tryptamine and dopa level in the brain of animal with depression, and can resist exhaust of monoamine transmitter caused by reserpine.

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