Provided are compounds of formula (III) useful for modulation of immune responses, compositions comprising the compounds, and methods of use of such compositions for treating diseases or disorders involving an immune response. In certain embodiments, the compounds are useful for the treatment of diseases or disorders associated with transendothelial migration of T cells and activated T cells, and proinflammatory cytokine production from T cells and macrophages. Diseases or disorders that can be ...

Provided are compounds of formula (III) useful for modulation of immune responses, compositions comprising the compounds, and methods of use of such compositions for treating diseases or disorders involving an immune response. In certain embodiments, the compounds are useful for the treatment of diseases or disorders associated with transendothelial migration of T cells and activated T cells, and proinflammatory cytokine production from T cells and macrophages. Diseases or disorders that can be ...

The present invention relates generally to modulation of immune responses by administration of compositions comprising macrolide antibiotics, such as roxithromycin, and use of those compositions in methods for treating or preventing diseases or disorders involving transendothelial migration of T cells and activated T cells, proinflammatory cytokine production from T cells, and IL-6 production from macrophages. The present invention further relates to the use of such macrolide antibiotic composit...