The present invention relates to a method for the preparation of trilostane from (4α5α17β)-45-epoxyandrost-2-eno(23-d)isoxazol-17-o1 as a precursor compound the method comprising the steps of a) dissolving the precursor compound in methanol; b) treating the precursor compound with a base to effect cleavage of the (23-d) isoxazole ring of the precursor compound; c) adding acid and water to the product of step b) to obtain a precipitate of Trilostanc; and d) isolating the precipitate of Trilostane...