The present invention relates to methods and compositions for the treatment of proliferative diseases comprising the administration of a combination of a taxane and at least one other and other therapeutic agents, as well as other treatment modalities useful in the treatment of proliferative diseases. In particular, the invention relates to the use of nanoparticles comprising paclitaxel and albumin (such as Abraxane*) in combination with other chemotherapeutic agents or radiation, which may be u...

PROBLEM TO BE SOLVED: To provide a method for treating proliferative diseases such as cancer.

PROBLEM TO BE SOLVED: To provide a method and composition for the treatment of proliferative diseases, comprising the administration of a combination of a taxane and at least one of other therapeutic agents, and to provide other treatment methods useful in the treatment of proliferative diseases.

The present invention provides methods and compositions for treating non-small-cell lung cancer (NSCLC) by administering a) a composition comprising nanoparticles that comprise paclitaxel and an albumin and b) a platinum-based agent (e.g., carboplatin). The present application also provides methods of treating prostate cancer by administering to the individual a) an effective amount of a composition comprising nanoparticles comprising docetaxel and an albumin

Disclosed are combination therapy methods of treating proliferative diseases (such as cancer) comprising a first therapy comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a second therapy which may include, for example, radiation, surgery, administration of chemotherapeutic agents (such as an anti-VEGF antibody), or combinations thereof. Also provided are methods of administering to an individual a drug taxane in a nanoparticle compositi...

PROBLEM TO BE SOLVED: To provide a method for reducing one or more side effects of administration of the pharmaceutical composition, the method for inhibiting microbial growth and oxidation in the pharmaceutical composition, and the method for enhancing transport and binding of a pharmaceutical agent to a cell, and to provide the pharmaceutical composition.

The present invention provides combination therapy methods of treating a proliferative disease (such as cancer) comprising administering to an individual an effective amount of a colchicine or thiocolchicine dimer and an anti-VEGF antibody. The method may further comprise administering an effective amount of a taxane. The colchicine or thiocolchicine dimer and the taxane (such as paclitaxel) may be present in the form of nanoparticles, such as nanoparticles comprising the drug and a carrier prot...

PROBLEM TO BE SOLVED: To provide a method for preparing nanoparticles consisting of paclitaxel and albumin having antitumor properties.SOLUTION: This method comprises adding powdery paclitaxel and chloroform to an aqueous solution of albumin to give a mixture and homogenizing the mixture under high pressure.COPYRIGHT: (C)2004JPO