LA INVENCION SE REFIERE A UN METODO PARA LA SINTESIS DE FOSCARNET ES DECIR DE HEXAHIDRATO DE FOSFONOFORMIATO TRISODICO QUE CONSISTE EN AÑADIR HIDROXIDO SODICO A AGUA CALENTAR LA SOLUCION DE HIDROXIDO SODICO ACUOSA A 50 C AÑADIR FOSFONOFORMIATO DE TRIETILO A DICHA SOLUCION A 50 C CALENTAR LA MEZCLA DE REACCION PARA QUE REFLUYA DURANTE UNA HORA APROXIMADAMENTE ENFRIAR LA MEZCLA DE REACCION Y FILTRAR EL PRODUCTO.

The present invention relates to a method for the synthesis of foscarnet i.e. trisodium phosphonoformate hexahydrate comprising the steps of adding sodium hydroxide to water heating the aqueous sodium hydroxide solution to 50 °C adding triethyl phosphonoformate to said solution at 50 °C heating the reaction mixture to reflux for about 1 hour cooling of the reaction mixture and filtering-off of the product.

The present invention relates to a method for the synthesis of foscarnet i.e. trisodium phosphonoformate hexahydrate comprising the steps of adding sodium hydroxide to water heating the aqueous sodium hydroxide solution to 50 °C adding triethyl phosphonoformate to said solution at 50 °C heating the reaction mixture to reflux for about 1 hour cooling of the reaction mixture and filtering-off of the product.