The captopril tablets have better stability and their production is made easier. The standard deviation of the active component content in one tablet, in one half or one quarter of it is very low. The tablets include a filler and a binder, decomposition substance and lubricant and slipping substance. The filler and the binder are a mixture of lactose and microcrystalline cellulose in weight ratios 1.5:1-1:1 which mixture represents from 60 to 80 wt.% of the total weight of the tablet. 12 claims

1. Captopril tablets comprising a filler and binding agent, a disintegrating agent, a lubricant and a glidant agent wherein the filler and binding agent is a 1.5:1 - 1:1 weight ratio mixture of lactose and microcrystalline cellulose and the total amount of said mixture is 60-80 % by weight of the total weight of the tablet. 2. Tablets according to claim 1 wherein the total amount of the mixture of lactose and microcrystalline cellulose is 67-75 % by weight of the total weight of the tablets. 3. ...

The invention relates to captopril tablets comprising a filler and binding agent, a disintegrating agent, a lubricant and a glidant agent wherein the filler and binding agent is a 1.5:1 - 1:1 weight ratio mixture of lactose and microcrystalline cellulose and the total amount of said mixture is 60-80 % by weight of the total weight of the tablet. The captopril tablets of the present invention are highly stable, can be readily manufactured and the standard deviation of the active ingredient conten...

The captopril tablets have better stability and theirproduction is made easier. The standard deviation of the activecomponent content in one tablet, in one half or one quarter of itis very low. The tablets include a filler and a binder,decomposition substance and lubricant and slipping substance. Thefiller and the binder are a mixture of lactose andmicrocrystalline cellulose in weight ratios 1.5:1-1:1 whichmixture represents from 60 to 80 wt.% of the total weight of thetablet.12 claims

The invention relates to captopril tablets comprising a filler and binding agent, a disintegrating agent, a lubricant and a glidant agent wherein the filler and binding agent is a 1.5:1 - 1:1 weight ratio mixture of lactose and microcrystalline cellulose and the total amount of said mixture is 60-80 % by weight of the totalweight of the tablet. The captopril tablets of the present invention are highly stable, can be readily manufactured and the standard deviation of the active ingredient content...

The invention relates to a novel process for preparing 1-[/2S/-methyl-3-mercaptopropionyl]-pyrrolidine-/2S/-carboxylic acid of the formula Iin which 1-[/2S/-methyl-3-thiocyanatopropionyl]-pyrrolidine-/2S/-carboxylic acid of the formula IIis dissolved in an aqueous mineral acid, the solution obtained is diluted with water and the 1-[/2S/-methyl-3- carbamoylthio-propionyl]-pyrrolidine-/2S/-carboxylic acid of the formula IIIthat forms is hydrolized with an aqueous solution of a base.t

The invention relates to a novel process for preparing 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-L-proline (captopril) of formula (I). (I) which comprises hydrogenolysing 1-[(2S)-2-methyl-1-oxo-3-rhodanidopropyl]-L-proline of formula (II) (II) in an inert solvent, in the presence of a catalyst, at a temperature of 50 DEG to 120 DEG C. under a pressure of 105 to 107 Pa. The above compound of formula (II) is new and can be prepared by acylating L-proline with a reactive acylating de...

1-(3'-rhodanido)-2'-(methyl)-propionyl)-pyrrolidine-2- carboxylic acid of formula (I) is new. USE/ADVANTAGE - (I) (Esp. the 2s, 2's-enantiomer) is an intermediate in the prepn. of 1-(3'-(mercapto)-(2's)- (methyl)-propionyl)-pyrrolidine I -(2s)-carboxylic acid (captopril) which can be used to reduce blood pressure. The prepn. of captopril from L-proline via (I) gives yields of more than 50% (based on L-proline, compared to e.g. a previous process using 3-(ethanoylthio)-2-(methyl)-propionic acid a...