A method for the manufacture of metoprolol wherein the process is performed in water as solvent.

FIELD: organic chemistry, chemical technology, medicine, pharmacy. SUBSTANCE: invention relates to the improved method for preparing metoprolol that is the known medicinal agent used in treatment of patients with arrythmia and myocardium infarct. At the first stage p-(2-methoxyethyl)-phenol and epichlorohydrin are subjected for interaction in water as a solvent in the coarse of a base addition and excess of epichlorohydrin is evaporated at temperature 50-70 C and obtained 1-(2,3-epoxypropoxy)-4-...

A method for the manufacture of metoprolol, characterized by reacting in a first step p-(2-methoxyethyl)phenol and epichlorohydrin in water as solvent during the addition of sodium or potassium hydroxide and at a temperature of 50 to 70 DEG C, evaporating the excess of epichlorohydrin and then distilling the obtained 1-(2,3-epoxypropoxy)-4-(2-methoxyethyl)-benzene under reduced pressure, and in a second step reacting the obtained 1-(2,3-epoxypropoxy)-4-(2-methoxyethyl)-benzene and isopropylamine...

A method for the manufacture of metoprolol wherein the process is performed in water as solvent.

Disclosed is a manufacturing process of metoprolol comprising in the first stage the reaction p-(2-methoxyethyl)phenol and epichlorohydrin in aqueous diluent with presence of lye or potash hydroxide under the temperature from 50 to 70 C, transpiration of epichlorohydrine surplus and then distillation of obtained 1-(2,3-epoxypropoxy)-4-(2-methoxyethyl)-benzoine under the lowered pressure, and in the second stage the reaction of obtained 1-(2,3-epoxypropoxy)-4-(2-methoxyethyl)benzoine and isopropy...

A method for the manufacture of metoprolol wherein the process is performed in water as solvent.

A method for the manufacture of metoprolol wherein the process is performed in water as solvent.