An improved process for the preparation of p-hydroxybenzyl cyanide by the reaction of p-hydroxybenzyl alcohol with an alkali metal cyanide, by carrying out the process in the presence of an alkyl formate, especially n-propyl formate. The cyanide product is a valuable intermediate for the preparation of the beta -adrenergic blocking agent atenolol.

The preparation of p- hydroxyphenylacetic acid by reducing p-hydroxymandelic acid with a stannous salt is described. The product is a valuable intermediate for the preparation of the beta -adrenergic blocking agent atenolol.

A process for the manufacture of p-hydroxyphenylacetic acid by the reduction of p-hydroxymandelic acid. The product is a useful intermediate for the preparation of the beta -adrenergic blocking agent atenolol.

Solid sodium or potassium p-hydroxymandelate monohydrate and a process for isolating it from a known reaction mixture of phenol, glyoxylic acid and sodium or potassium hydroxide. The product is a useful intermediate for the preparation of the beta -adrenergic blocking agent atenolol.