A suppository composition for vaginal administration of clindamycin which composition comprises an antimicrobially effective amount of clindamycin, or a pharmaceutically acceptable salt or ester thereof, dispersed in a Hard Fat suppository base.

4209 Process for preparing clindamycin and analogs thereof by reacting lincomycin or an analog thereof with a dimethylformamide and an excess of thionyl halide.

Novel useful analogs of the well known antibiotics lincomycin and clindamycin. These analogs are prepared by condensing a cyclic acid with a sugar amine and are represented by the general formula: wherein R1, which can be singly or multiply substituted in the 2, 3, 4, 5, 6, 7, 8 or 9 position of the ring not already substituted by R2, is hydrogen, alkyl and substituted alkyl, wherein the alkyl portion is from 1 to 8 carbon atoms, and isomeric forms thereof, cycloalkyl and substituted cyclo...

Novel useful analogs of the well known antibiotics lincomycin and clindamycin. These analogs are prepared by condensing a cyclic acid with a sugar amine and are represented by the general formula: wherein A, B, D and E are nitrogen, Cl--N , oxygen, sulfur or CR1R1;wherein R1, which can be singly or multiply attached to any ring carbon atom not already substituted by R2, is hydrogen, alkyl and substituted alkyl, wherein the alkyl portion is from 1 to 8 carbon atoms, and isomeric forms ...

Novel useful analogs of the well known antibiotics lincomycin and clindamycin. These analogs are prepared by condensing a cyclic acid with a sugar amine and are re¦presented by the general formula: wherein A, B and E are nitrogen, CH3-N?, oxygen, sulfur or CR1R1;wherein R1, which can be singly or multiply attached to any ring carbon atom not already substituted by R2, is hydrogen, alkyl and substituted alkyl, wherein the alkyl portion is from 1 to 8 carbon atoms, and isomeric forms thereof...