NEW MATERIAL:The compound of formula I (R is H or methyl) and its acid addition salt.EXAMPLE: 6'-N-Formimidoyl amikacin.USE: Semisynthetic amino glycoside antibiotic substance effective widely against resistant bacteria.PROCESS: The 6'-amino group of kanamycin is exclusively protected the 3- and 3"-amino groups are protected with amino-protecting groups different from the group used for the protection of the 6'-amino group the remaining 1-amino group is acylated with an (amino-protected) 4-amino...

NEW MATERIAL:The compound of formula I (R is H or methyl) and its acid addition salt. EXAMPLE:6'-N-Formimidoyl amikacin. USE:Semisynthetic amino glycoside antibiotic substance effective widely against resistant bacteria. PROCESS:The 6'-amino group of kanamycin is exclusively protected, the 3- and 3''-amino groups are protected with amino-protecting groups different from the group used for the protection of the 6'-amino group, the remaining 1-amino group is acylated with an (amino-protected) 4-am...

NEW MATERIAL:The compound of formula I (R is H or methyl) and its acid addition salt.EXAMPLE: 6'-N-Formimidoyl amikacin.USE: Semisynthetic amino glycoside antibiotic substance effective widely against resistant bacteria.PROCESS: The 6'-amino group of kanamycin is exclusively protected the 3- and 3"-amino groups are protected with amino-protecting groups different from the group used for the protection of the 6'-amino group the remaining 1-amino group is acylated with an (amino-protected) 4-amino...

NEW MATERIAL:3'4'4"6"-Tetradeoxyamikacin of formula I and its acid addition salt.USE: An antimicrobial agent having lower toxicity to the hearing orgen as well as acute toxicity than amikacin used as a raw material. It is effective to a side variety of resistant microorganisms.PROCESS: The compound of formula I is prepared by (1) introducing a protecting group to 3'4'-dioxyamikacin of formula II (2) removing the 4" and 6"-protecting groups from the resulting compound of formula III [A is H; B is...

NEW MATERIAL:An amikacin derivative of formula I (R is OH or H) and its acid addition salt.USE: Remedy for bacterial infectious diseases causing little damages to the faculty of hearing.PROCESS: The objective compound of formula I wherein R is H is prepared e.g. by (1) protecting the four NH(sub 2) groups of amikacin of formula II with amino-protecting groups (2) protecting the two OH groups with one bivalent OH-protecting group (3) protecting the remaining five OH groups at 2' 3' 4' 2" and 2'''...

PURPOSETo obtain the title substance useful for preparing antibiotic amikacin by forming a complex from an aminoglycoside antibiotic e.g. kanamycin gentamicin or sisomicin with zinc cations and by acylating the complex. CONSTITUTIONAn aminoglycoside antibiotic consisting of deoxystreptamine having an 3-aminoglycosyl or 3-alkylaminoglycosyl group at the 6-position e.g. a compound of the formula (Rlt;1gt; is OH or NH2; Rlt;2gt; and Rlt;3gt; are H or OH; Rlt;4gt; is OH NH2 or 1-4C alkylamino group)...