In the present invention, there is disclosed a process for preparing trans-4-methylcyclohexylamine of the general formula V, optionally a corresponding trans-4-methylcyclohexylamine hydrochloride of the general formula VIII or pivalate of the general formula VII exhibiting high content of trans-isomer, wherein the preparation process is characterized by the following steps: a) subjecting a Schiff's base of the general formula to isomerization by treating thereof with a strong base in a solvent b...

The present invention relates to a process for preparing glimepiride of the general formula I wherein the preparation process is characterized by reacting trans-4-methylcyclohexyl amine pivalate of the general formula VII, either directly or after conversion to trans-4-methylcyclohexyl amine, optionally another salt thereof, with alkyl-[4-(2-{[(3-ethyl-4-methyl-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)carbonyl]amino}ethyl)phenyl]-sulfonyl carbamate of the general formula IV, in which R represents alkyl ...