专利信息

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专利标题：Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase iv and method

Dipeptidyl peptidase IV (DP 4) inhibiting compounds are provided having the formula where x is 0 or 1 and y is 0 or 1 (provided that x=1 when y=0 and x=0 when y=1); n is 0 or 1; X is H or CN; and wherein R1 R2 R3 and R4 are as described herein. A method is also provided for treating diabetes and related diseases especially Type II diabetes and other diseases as set out herein employing such DP 4 inhibitor *or a combination of such DP 4 inhibitor and one or more of another antidiabetic agent such...

专利标题：Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase iv and method

专利权人：BRISTOL-MYERS SQUIBB COMPANY;

Dipeptidyl peptidase IV (DP 4) inhibiting compounds are provided having the formula (I) where x is 0 or 1 and y is 0 or 1 (provided that x = 1 when y = 0 and x = 0 when y = 1); n is 0 or 1; X is H or CN; and wherein R1 R2 R3 and R4 are as described herein. A method is also provided for treating diabetes and related diseases especially Type II diabetes and other diseases as set out herein employing such DP 4 inhibitor or a combination of such DP 4 inhibitor and one or more of another antidiabetic...

专利标题：Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase iv, process for their preparation and their use

专利权人：BRISTOL-MYERS SQUIBB COMPANY;

Dipeptidyl peptidase IV (DP 4) inhibiting compounds are provided having the formula (I) where x is 0 or 1 and y is 0 or 1 (provided that x = 1 when y = 0 and x = 0 when y = 1); n is 0 or 1; X is H; and wherein R1 R2 R3 and R4 are as described herein. A method is also provided for treating diabetes and related diseases especially Type II diabetes and other diseases as set out herein employing such DP 4 inhibitor or a combination of such DP 4 inhibitor and one or more of another antidiabetic agent...

专利标题：Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase iv

专利权人：BRISTOL-MYERS SQUIBB COMPANY;

Dipeptidyl peptidase IV (DP 4) inhibiting compounds are provided having the formula where x is 0 or 1 and y is 0 or 1 (provided that x=1 when y=0 and x=0 when y=1); n is 0 or 1; X is H or CN; and wherein R1 R2 R3 and R4 are as described herein. A method is also provided for treating diabetes and related diseases especially type II diabetes and other diseases as set out herein employing such DP 4 inhibitor or a combination of such DP 4 inhibitor and one or more of another antidiabetic agent such ...

专利标题：Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein

专利权人：BRISTOL-MYERS SQUIBB COMPANY;

Compounds that are dual aP2/k-FABP inhibitors are provided having the formulawherein A B X Y R1 R2 and R3 are as described herein. A method is also provided for treating diabetes and related diseases especially Type II diabetes employing dual aP2/k-FABP inhibitors alone or in combination with at least one other antidiabetic agent such as metformin glyburide troglitazone and/or insulin.

专利标题：Heterocyclic containing biphenyl ap2 inhibitors and method

专利权人：BRISTOL-MYERS SQUIBB COMPANY;

aP2 inhibiting compounds are provided having the formulawherein R1 R2 R3 R4 X—Z andare as described herein.A method is also provided for treating diabetes and related diseases especially Type II diabetes employing such aP2 inhibitor or a combination of such aP2 inhibitor and another antidiabetic agent such as metformin glyburide troglitazone and/or insulin.

专利标题：Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein

专利权人：BRISTOL-MYERS SQUIBB COMPANY;

Compounds that are dual aP2/k-FABP inhibitors are provided having the formula (I) wherein A B X Y R1 R2 and R3 are as described herein. A method is also provided for treating diabetes and related diseases especially Type II diabetes employing dual aP2/k-FABP inhibitors alone or in combination with at least one other antidiabetic agent such as metformin glyburide troglitazone and/or insulin.

专利标题：Pyridone inhibitors of fatty acid binding protein and method

专利权人：BRISTOL-MYERS SQUIBB COMPANY;

Compounds are provided having the formula:wherein A Q and X are as described herein.A method is also provided for treating diabetes and related diseases especially Type II diabetes employing such compounds alone or in combination with other antidiabetic agents such as metformin glyburide troglitazone and/or insulin.

专利标题：Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein

专利权人：BRISTOL-MYERS SQUIBB COMPANY;

Compounds that are dual aP2/k-FABP inhibitors are provided having the formula1wherein A B X Y R1 R2 and R3 are as described herein.A method is also provided for treating diabetes and related diseases especially Type II diabetes employing dual aP2/k-FABP inhibitors alone or in combination with at least one other antidiabetic agent such as metformin glyburide troglitazone and/or insulin.

专利标题：Tetrahydropyrimidone inhibitors of fatty acid binding protein and method

专利权人：BRISTOL-MYERS SQUIBB COMPANY;

aP2 inhibiting compounds are provided having the formulawherein A B X and Y are as described herein.A method is also provided for treating diabetes and related diseases especially Type II diabetes employing such aP2 inhibitor or a combination of such aP2 inhibitor and another antidiabetic agent such as metformin glyburide troglitazone and/or insulin.

当前查询条件: [专利权人] 包含 'BRISTOL-MYERS SQUIBB COMPANY' AND [药品] 包含 'Troglitazone'

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!	专利类型	发明实用新型外观设计
!	公开号			CN1234
!	申请号			CN1234
!	专利标题		扩展	PHARMA
!	专利权人		扩展	pfizer
	发明人
!	申请日			yyyymmdd
!	公开日			yyyymmdd
	优先权号
!	摘要		扩展	PHARMA
	IPC			A01B

1. USRE44186E1	2013/4/30	US13/308658	2011/12/1
专利标题：Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase iv and method 专利权人：BRISTOL-MYERS SQUIBB COMPANY; Dipeptidyl peptidase IV (DP 4) inhibiting compounds are provided having the formula where x is 0 or 1 and y is 0 or 1 (provided that x=1 when y=0 and x=0 when y=1); n is 0 or 1; X is H or CN; and wherein R1 R2 R3 and R4 are as described herein. A method is also provided for treating diabetes and related diseases especially Type II diabetes and other diseases as set out herein employing such DP 4 inhibitor *or a combination of such DP 4 inhibitor and one or more of another antidiabetic agent such...

2. CA2402894C	2012/4/17	CA20012402894	2001/3/5
专利标题：Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase iv and method 专利权人：BRISTOL-MYERS SQUIBB COMPANY; Dipeptidyl peptidase IV (DP 4) inhibiting compounds are provided having the formula (I) where x is 0 or 1 and y is 0 or 1 (provided that x = 1 when y = 0 and x = 0 when y = 1); n is 0 or 1; X is H or CN; and wherein R1 R2 R3 and R4 are as described herein. A method is also provided for treating diabetes and related diseases especially Type II diabetes and other diseases as set out herein employing such DP 4 inhibitor or a combination of such DP 4 inhibitor and one or more of another antidiabetic...

3. EP1559710A3	2009/7/22	EP20050005368	2001/3/5
专利标题：Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase iv, process for their preparation and their use 专利权人：BRISTOL-MYERS SQUIBB COMPANY; Dipeptidyl peptidase IV (DP 4) inhibiting compounds are provided having the formula (I) where x is 0 or 1 and y is 0 or 1 (provided that x = 1 when y = 0 and x = 0 when y = 1); n is 0 or 1; X is H; and wherein R1 R2 R3 and R4 are as described herein. A method is also provided for treating diabetes and related diseases especially Type II diabetes and other diseases as set out herein employing such DP 4 inhibitor or a combination of such DP 4 inhibitor and one or more of another antidiabetic agent...

4. TWI258468B	2006/7/21	TW20010104965	2001/3/5
专利标题：Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase iv 专利权人：BRISTOL-MYERS SQUIBB COMPANY; Dipeptidyl peptidase IV (DP 4) inhibiting compounds are provided having the formula where x is 0 or 1 and y is 0 or 1 (provided that x=1 when y=0 and x=0 when y=1); n is 0 or 1; X is H or CN; and wherein R1 R2 R3 and R4 are as described herein. A method is also provided for treating diabetes and related diseases especially type II diabetes and other diseases as set out herein employing such DP 4 inhibitor or a combination of such DP 4 inhibitor and one or more of another antidiabetic agent such ...

5. US6984645B2	2006/1/10	US10/295819	2002/11/15
专利标题：Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein 专利权人：BRISTOL-MYERS SQUIBB COMPANY; Compounds that are dual aP2/k-FABP inhibitors are provided having the formulawherein A B X Y R1 R2 and R3 are as described herein. A method is also provided for treating diabetes and related diseases especially Type II diabetes employing dual aP2/k-FABP inhibitors alone or in combination with at least one other antidiabetic agent such as metformin glyburide troglitazone and/or insulin.

6. US6927227B2	2005/8/9	US10/321137	2002/12/17
专利标题：Heterocyclic containing biphenyl ap2 inhibitors and method 专利权人：BRISTOL-MYERS SQUIBB COMPANY; aP2 inhibiting compounds are provided having the formulawherein R1 R2 R3 R4 X—Z andare as described herein.A method is also provided for treating diabetes and related diseases especially Type II diabetes employing such aP2 inhibitor or a combination of such aP2 inhibitor and another antidiabetic agent such as metformin glyburide troglitazone and/or insulin.

7. EP1443919A1	2004/8/11	EP20020782300	2002/11/15
专利标题：Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein 专利权人：BRISTOL-MYERS SQUIBB COMPANY; Compounds that are dual aP2/k-FABP inhibitors are provided having the formula (I) wherein A B X Y R1 R2 and R3 are as described herein. A method is also provided for treating diabetes and related diseases especially Type II diabetes employing dual aP2/k-FABP inhibitors alone or in combination with at least one other antidiabetic agent such as metformin glyburide troglitazone and/or insulin.

8. US6670380B2	2003/12/30	US09/989212	2001/11/20
专利标题：Pyridone inhibitors of fatty acid binding protein and method 专利权人：BRISTOL-MYERS SQUIBB COMPANY; Compounds are provided having the formula:wherein A Q and X are as described herein.A method is also provided for treating diabetes and related diseases especially Type II diabetes employing such compounds alone or in combination with other antidiabetic agents such as metformin glyburide troglitazone and/or insulin.

9. US20030225091A1	2003/12/4	US10/295819	2002/11/15
专利标题：Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein 专利权人：BRISTOL-MYERS SQUIBB COMPANY; Compounds that are dual aP2/k-FABP inhibitors are provided having the formula1wherein A B X Y R1 R2 and R3 are as described herein.A method is also provided for treating diabetes and related diseases especially Type II diabetes employing dual aP2/k-FABP inhibitors alone or in combination with at least one other antidiabetic agent such as metformin glyburide troglitazone and/or insulin.

10. US6649622B2	2003/11/18	US09/771310	2001/1/26
专利标题：Tetrahydropyrimidone inhibitors of fatty acid binding protein and method 专利权人：BRISTOL-MYERS SQUIBB COMPANY; aP2 inhibiting compounds are provided having the formulawherein A B X and Y are as described herein.A method is also provided for treating diabetes and related diseases especially Type II diabetes employing such aP2 inhibitor or a combination of such aP2 inhibitor and another antidiabetic agent such as metformin glyburide troglitazone and/or insulin.

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