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SQUIBB BRISTOL MYERS CO [US](34)
ASTRAZENECA UK LTD [GB](4)
PIPER BETH ANNE [US](2)
PATEL JATIN M [US](1)
ABEBE ADMASSU [US](1)
TIMMINS PETER [US](1)
MARTIN KYLE [US](1)
ASTRAZENECA UK LTD [GB](1)
ABEBE ADMASSU [US](1)
MARTIN KYLE [US](1)
专利信息
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[专利权人] 包含 'SQUIBB BRISTOL MYERS CO [US]'
[药品] 包含 'Metformin '
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公开号
公开日
申请号
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1.
US2012294936A1
2012/11/22
US201013509206
2010/11/12
专利标题
:REDUCED MASS METFORMIN FORMULATIONS
专利权人
:
ASTRAZENECA UK LTD [GB]
;
SQUIBB BRISTOL MYERS CO [US]
;
The present invention relates to metformin extended release (XR) formulations with improved compactability to provide reduced mass tablets, granulations, and capsules.
2.
US2012282336A1
2012/11/8
US201013509210
2010/11/12
专利标题
:BILAYER TABLET FORMULATIONS
专利权人
:
ASTRAZENECA UK LTD [GB]
;
SQUIBB BRISTOL MYERS CO [US]
;
The present invention relates to bilayer tablet formulations comprising metformin extended release (XR) or reduced mass metformin XR formulation as the first layer, an SGLT2 inhibitor formulation as the second layer, and optionally a film coating. The present invention provides methods of preparing the bilayer tablet formulations and methods of treating diseases or disorders associated with SGLT2 activity employing the bilayer tablet formulations.
3.
EP2498757A1
2012/9/19
EP20100782112
2010/11/12
专利标题
:REDUCED MASS METFORMIN FORMULATIONS
专利权人
:
SQUIBB BRISTOL MYERS CO [US]
;
ASTRAZENECA UK LTD [GB]
;
4.
MX2012005416A
2012/6/14
MX20120005416
2012/5/9
专利标题
:BILAYER TABLET FORMULATIONS.
专利权人
:
SQUIBB BRISTOL MYERS CO [US]
;
The present invention relates to bilayer tablet formulations comprising metformin extended release (XR) or reduced mass metformin XR formulation as the first layer, an SGLT2 inhibitor formulation as the second layer, and optionally a film coating. The present invention provides methods of preparing the bilayer tablet formulations and methods of treating diseases or disorders associated with SGLT2 activity employing the bilayer tablet formulations.
5.
MX2012005365A
2012/5/29
MX20120005365
2012/5/8
专利标题
:IMMEDIATE RELEASE TABLET FORMULATIONS.
专利权人
:
SQUIBB BRISTOL MYERS CO [US]
;
The present invention provides an immediate release pharmaceutical formulation which includes a tablet or capsule formulation comprising metformin and the sodium dependent glucose transporter (SGLT2) inhibitor dapagliflozin or its propylene glycol hydrate. The present invention also provides methods of preparing the formulations and methods of treating diseases or disorders associated with SGLT2 activity employing these formulations.
6.
EP2332522A2
2011/6/15
EP20110160470
1999/3/10
专利标题
:Biphasic controlled release delivery system for high solubility pharmaceuticals and method
专利权人
:
SQUIBB BRISTOL MYERS CO [US]
;
A biphasic controlled release delivery system for pharmaceuticals which have high water solubility, such as the antidiabetic metformin HCl salt, is provided which provides a dosage form that has prolonged gastric residence and includes (1) an inner solid particulate phase formed of substantially uniform granules containing a pharmaceutical having a high water solubility, and one or more hydrophilic polymers, one or more hydrophobic polymers and/or one or more hydrophobic materials such as one or...
7.
WO2011060255A1
2011/5/19
WO2010US56525
2010/11/12
专利标题
:REDUCED MASS METFORMIN FORMULATIONS
专利权人
:
SQUIBB BRISTOL MYERS CO [US]
;
PATEL JATIN M [US]
;
ASTRAZENECA UK LTD [GB]
;
ABEBE ADMASSU [US]
;
TIMMINS PETER [US]
;
MARTIN KYLE [US]
;
The present invention relates to metformin extended release (XR) formulations with improved compactability to provide reduced mass tablets, granulations, and capsules.
8.
WO2011060256A2
2011/5/19
WO2010US56529
2010/11/12
专利标题
:BILAYER TABLET FORMULATIONS
专利权人
:
SQUIBB BRISTOL MYERS CO [US]
;
ASTRAZENECA UK LTD [GB]
;
ABEBE ADMASSU [US]
;
MARTIN KYLE [US]
;
PATEL JATIN M [US]
;
DESAI DIVYAKANT [US]
;
TIMMINS PETER [US]
;
The present invention relates to bilayer tablet formulations comprising metformin extended release (XR) or reduced mass metformin XR formulation as the first layer, an SGLT2 inhibitor formulation as the second layer, and optionally a film coating. The present invention provides methods of preparing the bilayer tablet formulations and methods of treating diseases or disorders associated with SGLT2 activity employing the bilayer tablet formulations.
9.
RO123109B1
2010/11/30
RO20020000560
2000/10/13
专利标题
:UTILIZATION OF A COMPOSITION BASED ON METFORMIN AND GLYBURIDE FOR TREATING TYPE 2 DIABETES
专利权人
:
SQUIBB BRISTOL MYERS CO [US]
;
The invention relates to the utilization of metformin and glyburide for preparing a pharmaceutical composition which comprises a low dose of a combination of metformin and glyburide, containing 250 mg metformin/1.25 mg glyburide in which the particle size distribution is such that utmost 10% of glyburide particles are less than 2 mu m and utmost 10% of the particles are greater than 60 mu m for the first line therapy of the type 2 diabetes, in a drug treatment naive human patient, in which metfo...
10.
CN101273981A
2008/10/1
CN20081081755
2000/10/13
专利标题
:Preparation and method for treating diabetes
专利权人
:
SQUIBB BRISTOL MYERS CO [US]
;
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