Novel mono-alkyl substituted and dialkyl substituted 2-alkyl-5-carbamoyl pyrazines are prepared by reacting a 2-alkyl-5-carboxy-pyrazine with a monoalkyl amine or dialkyl amine respectively where the alkyl groups contain 1 to 4 C atoms. The invention also includes 2,5-dimethyl pyrazine p-toluene sulphonate and its preparation by reacting 2,5-dimethyl pyrazine with p-toluene-sulphonic acid, and the salts of the above carbamoyl derivatives. The compounds have therapeutic properties. The preparatio...

3,5-Disubstituted pyrazoles of formula wherein R1 is alkyl and R2 is carboxyl, carbamoyl, alkoxycarbonyl, or alkyl monosubstituted carbamoyl, alkyl being C1 to C4, are prepared by reacting together hydrazine and an appropriate keto-acid

The invention comprises N-arylsulphonyl-N1-tetrahydropyridyl ureas of the formula and pharmacologically acceptable acid addition salts thereof, wherein X and Y are hydrogen, C1-8 alkyl or alkoxy, C2-5 alkanoyl, halogen, e.g. Cl, Br or F, or primary amino (NH2) and R, R1 and R2 are hydrogen or C1-4 alkyl, e.g. p-methyl-and p-chloro-benzenesulphonyl-N1 -(1,2,3,6-tetrahydropyridyl-(1)) ureas, and their preparation by (a) reacting a 1-amino-tetrahydropyridine with the appropriate...