Disclosed is a dividable prolonged-release tablet comprising gliclazide, a cellulose derivative selected from the group consisting of hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose and/or hydroxypropyl methylcellulose and a binder selected from the group consisting of maltodextrin, polyvidone or a hydroxypropyl methylcellulose of very low viscosity, wherein the non-subdivided tablet and a portion of said tablet obtained by subdivision have similar dissolution profiles.

PROBLEM TO BE SOLVED: To provide a core tablet for the controlled release of gliclazide. ; SOLUTION: The core tablet for the controlled release of gliclazide ensures continuous and constant release of the active principle, unaffected by the dissolving medium pH variations, after oral administration. The core tablet comprises at least a cellulose polymer compound and a glucose syrup, wherein the cellulose polymer compound is a mixture of two kinds of hydroxypropylmethylcelluloses of a different v...

A matrix tablet for the prolonged release of gliclazide comprises a combination of cellulose polymer compound and glucose syrup enabling the control of the prolonged release of gliclazide and enabling insensitivity of the dissolution kinetic of gliclazide to variations of pH.