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UNIV MARYLAND [US](4)
SIMARD J MARC [US](1)
MINGKUI CHEN [US](1)
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[专利权人] 包含 'UNIV MARYLAND [US]'
[药品] 包含 'Tolbutamide'
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1.
US2008139659A1
2008/6/12
US20070857547
2007/9/19
专利标题
:METHODS FOR TREATING NEURAL CELL SWELLING
专利权人
:
UNIV MARYLAND [US]
;
A composition comprising a novel Ca<2+>-activated, [ATP]i-sensitive nonspecific cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides, and is activated by submicromolar [Ca]i. The NCCa-ATP channel is activated under conditions of ATP depletion, which causes severe cell depolarization, followed by cell swelling. The NCCa-ATP channel is regulated by a sulfonylurea receptor and is inhibited...
2.
US2006276411A1
2006/12/7
US20060359946
2006/2/22
专利标题
:Novel non-selective cation channel in neuronal cells and methods for treating brain swelling
专利权人
:
UNIV MARYLAND [US]
;
The present invention is directed to therapeutic compounds, treatment methods, and kits affecting the NCCa-ATP channel of neural tissue, including neurons, glia and blood vessels within the nervous system, and methods of using same. The NCCa-ATP channel is newly expressed in neural tissue following injury such as ischemia, and is regulated by the sulfonylurea receptor SUR1, being inhibited by sulfonylurea compounds, e.g., glibenclamide and tolbutamide, and opened by diazoxide. Antagonists of the...
3.
WO03079987A2
2003/10/2
WO2003US08442
2003/3/20
专利标题
:A NON-SELECTIVE CATION CHANNEL IN NEURAL CELLS AND METHODS FOR TREATING BRAIN SWELLING
专利权人
:
UNIV MARYLAND [US]
;
SIMARD J MARC [US]
;
MINGKUI CHEN [US]
;
A composition comprising a novel Ca<2+>-activated, [ATP]i-sensitive nonspecific cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides, and is activated by submicromolar [Ca]i. The NCCa-ATP channel is activated under conditions of ATP depletion, which causes severe cell depolarization, followed by cell swelling. The NCCa-ATP channel is regulated by a sulfonylurea receptor and is inhibited...
4.
CA2477812A1
2003/10/2
CA20032477812
2003/3/20
专利标题
:A NON-SELECTIVE CATION CHANNEL IN NEURAL CELLS AND METHODS FOR TREATING BRAIN SWELLING
专利权人
:
UNIV MARYLAND [US]
;
A composition comprising a novel Ca2+-activated, [ATP]i-sensitive nonspecifi c cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenin e nucleotides, and is activated by submicromolar [Ca]i. The NCCa-ATP channel i s activated under conditions of ATP depletion, which causes severe cell depolarization, followed by cell swelling. The NCCa-ATP channel is regulated by a sulfonylurea receptor and is inhibite...
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