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公开号 公开日 申请号 申请日
1. US8318810B2 2012/11/27 US11/857547 2007/9/19
专利标题:Methods for treating neural cell swelling 法律状态
A composition comprising a novel Ca2+-activated [ATP]i-sensitive nonspecific cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides and is activated by submicromolar [Ca]i. The NCCa-ATP channel is activated under conditions of ATP depletion which causes severe cell depolarization followed by cell swelling. The NCCa-ATP channel is regulated by a sulfonylurea receptor and is inhibited by su...


2. US20080139659A1 2008/6/12 US11/857547 2007/9/19
专利标题:Methods for treating neural cell swelling 法律状态
A composition comprising a novel Ca2+-activated [ATP]i-sensitive nonspecific cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides and is activated by submicromolar [Ca]i. The NCCa-ATP channel is activated under conditions of ATP depletion which causes severe cell depolarization followed by cell swelling. The NCCa-ATP channel is regulated by a sulfonylurea receptor and is inhibited by su...


3. US7285574B2 2007/10/23 US11/099332 2005/4/5
专利标题:Methods for treating neural cell swelling 法律状态
A composition comprising a novel Ca2+-activated [ATP]i-sensitive nonspecific cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides and is activated by submicromolar [Ca]i. The NCCa-ATP channel is activated under conditions of ATP depletion which causes severe cell depolarization followed by cell swelling. The NCCa-ATP channel is regulated by a sulfonylurea receptor and is inhibited by su...



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