1313274 Hypoglycaemic compositions containing bicycloalkanecarboxamides UPJOHN CO 15 Dec 1971 [14 Jan 1971] 58331/71 Heading A5B [Also in Division C2] Pharmaceutical compositions, suitable for oral administration, contain novel bicycloalkanecarboxamides of the formula: wherein n is 1 to 3, x is 0 or 1, and R 1 is H, C 1-6 alkyl, 2-pyridyl, phenyl, or phenyl substituted by C 1-3 alkyl, C 1-3 alkoxy, halogen, NO 2 or CF 3 , together with suitable carriers and, if desired other active ingredients s...

A therapeutic tablet for lowering the blood sugar level comprises a slightly soluble hypoglycaemic sulphonyl urea compound and diotyl sodium sulphosuccinate. Specified sulphonyl urea compounds include those of general formula wherein R is methyl or chlorine, and R1 is alkyl, alicyclic, or heterocyclic e.g. tolbutamide, N-4-methyl-benzene sulphonyl-N1-cyclopentyl urea, N-4-methyl-benzene sulphonyl-N1-hexamethyleneimino urea. Inert non-caloric diluents may be added.

A therapeutic tablet for lowering the blood sugar level comprises a sulphonyl urea compound of general formula wherein R is methyl or chlorine and R1 is an alkyl, alicyclic, or heterocyclic group, and polyvinyl pyrrolidone. Specified sulphonyl urea compounds are tolbutamide, N-4-methyl-benzenesulphonyl - N1 - cyclopentylurea and N-4-methyl - benzenesulphonyl - N1 - hexamethyleneimino urea. Polyvinyl pyrrolidone may be added as an aqueous solution to the sulphonyl urea comp...

The invention comprises compounds of the general formula in which (a) R1 and R2 are methyl, R, R3, R4 and R5 are H and n is 1

Membranes formed by the coacervation of a material comprising at least one gelable hydrophilic colloid having amino groups and peptide linkages (e.g. proteins and polyamines) are treated with an aqueous solution of an alum of general formula M1M111(S)2.12H2O wherein M1 is ammonium or a monovalent metal, M111 is a trivalent metal and S represents a sulphate or selenate radical. The membranes may be formed by simple or complex coacervation of one or more of the above colloids by any process on to ...