The invention concerns omeprazole microgranules each comprising an active layer containing the active principle and an outer gastroprotecting layer containing a gastroprotecting agent characterized in that the omeprazole is combined with at least a hydrophobic substance.

A pharmaceutical formulation of a gastric proton pump inhibitor with the exception of omeprazole is disclosed. The formulation is in the form of microgranules insoluble in gastric fluid having improved stability over time. The formulation comprises several hydrophobic substances chosen in order to increase the stability of the active principle while obtaining the desired dissolution profile.

A pharmaceutical formulation of a gastric proton pump inhibitor with the exception of omeprazole is disclosed. The formulation is in the form of microgranules insoluble in gastric fluid having improved stability over time. The formulation comprises several hydrophobic substances chosen in order to increase the stability of the active principle while obtaining the desired dissolution profile.

PROBLEM TO BE SOLVED: To provide a fine granular preparation of a gastric proton pump inhibitor having long term stability and insoluble in a gastric juice. SOLUTION: The fine granular preparation is insoluble in gastric juice and includes the gastric proton pump inhibitor other than omeprazole an effective layer including an effective component and an outer layer providing insolubility in the gastric juice respectively wherein the effective layer and the layer providing insolubility in the gas...

The present invention relates to omeprazole microgranules that can be used for treating stomach or duodenal ulcers whereby each omeprazole microgranule comprises an active layer containing the active principle and an gastroprotecting layer containing a gastroprotecting agent. The invention is characterized in that omeprazole is combined in said active layer with a hydrophobic substance.

Omeprazole microgranules each comprising an active layer containing the active principle and an outer gastroprotecting layer containing a gastroprotecting agent. The microgranules further comprise at least one hydrophobic substance. Method of preparation of the granules and a pharmaceutical composition containing the microgranules.

The invention concerns microgranules insoluble in gastric fluid containing a gastric proton pump inhibitor except omeprazole comprising each an active layer containing the active principle and an external layer providing insolubility in gastric fluid. The invention is characterised in that the active layer and the layer providing insolubility in gastric fluid contain each a hydrophobic substance selected to increase the storage stability of the microgranules and characterised in that the microgr...