Sucralfate preparation produced by melt granulating a mixture of a comminuted sucralfate powder and a water-soluble low-melting point wax as well as a process for producing a sucralfate preparation comprising the steps of comminuting dry sucralfate into fine particles mixing the finely divided particles with a water-soluble low-melting point wax and heating the mixture such that the wax is melted to effect melt (adhesion) granulation of the finely divided sucralfate particles are disclosed. Comp...

A method of using an antacid for preventing sucralfate from adsorbing or trapping another drug as well as a pharmaceutical preparation comprising sucralfate another drug and an antacid such that the another drug is prevented from being adsorbed on or trapped by sucralfate are disclosed. The use of the antacid in an environment where sucralfate is used along with another drug can prevent the occurrence of interactions between sucralfate and the another drug such as inhibited or delayed absorption...

A sucralfate preparation prepared by melt granulating a mixture of a sucralfate powder with a water-soluble low-melting wax; and a process for producing a sucralfate preparation by atomizing dry sucralfate adding a water-soluble low-melting wax to the atomized powder and heat melting the wax to effect melt (fusion) granulation of the atomized sucralfate. As compared with conventional sucralfate preparations the above preparation is reduced in the size of dispersed particles has a high ability to...

A stock solution comprising an aqueous suspension containing 1 to 2 g/ml of sucralfate particles with a mean diameter of 50 Al or less which is used for producing sucralfate preparations; and a process for producing said stock solution which comprises dispersing wet sucralfate powder as such in water or an aqueous medium and disintegrating the dispersed powder into particles with a mean diameter of 50 Al or less. The stock solution thus obtained directly from the wet sucralfate powder has proper...

A coated antacid which is used for concoctions of sucralfate with an antacid prevents the adhering characteristics of sucralfate from lowering and permitting the administered drug to exhibit its activities in the stomach without fail. Specifically a gastrointestinal drug which is enhanced in the solubility of sucralfate in the stomach by inhibiting the reaction of an antacid with gastric hydrochloric acid in an early stage of arrival at the stomach to thereby make sucralfate exhibit a sufficient...

A sucralfate preparation containing an amino acid free from benzene ring and sulfur atoms in the chemical structure is disclosed. The preparation keeps its ability to form a sticky paste in gastric juice over an extended period and hence exhibits a sustained effect to protect the ulcer-affected mucosa of the stomach and duodenum.