PROBLEM TO BE SOLVED: To obtain the subject composition capable of improving the adhesive strength of sucralfate to a neutral mucosal upper stratal site in an anorectal region in the vagina or in the urethra promoting the persistence of protecting and therapeutic effects of an affected part and achieving the enhancement of healing effects by formulating sucralfate in a high ratio.SOLUTION: This composition contains (A) 50-80 wt.% of sucralfate (B) a pH adjustor (e.g. disodium citrate) in an amou...

PROBLEM TO BE SOLVED: To produce a liquid medicine containing a stabilized azulene derivative by performing deaerating of the liquid medicine containing the azulene derivative and substituting the head space with nitrogen.SOLUTION: This liquid medicine containing a stabilized azulene derivative is obtained by performing deaeration of the liquid medicine containing the azulene derivative to remove oxygen dissolving in the solution packing the oxygen-removed solution into a packing vessel and subs...

PURPOSE: To obtain the subject composition having guaranteed bioavailability of the drug without causing the adsorption and trapping of the drug to sucralfate in spite of the formulation of the preparation to compound the drug and sucralfate at the same time.CONSTITUTION: (A) Sucralfate and (B) other drug are compounded in the same preparation to effect the rapid dissolution of the component B without being adsorbed or trapped to the component A. Preferably the compound A is compounded together ...

PURPOSE: To obtain a sucralfate pharmaceutical preparation containing a specific organic carboxylic acid and sucralfate increased in adhesion of sucralfate to ulcer part of mucosa and applicable for lower digestive tract as well as ulcer gastric ulcer and duodenal ulcer.CONSTITUTION: The pharmaceutical preparation contains (A) an organic carboxylic acid (preferably malic acid) having >=2 carboxyl groups or hydroxyl groups and (B) sucralfate preferably in a ratio of composition in terms of weight...

PURPOSE: To obtain a sucralfate preparation having a small dispersion particle size high affinity for plasma protein and excellent medication by melting and granulating pulverized sucralfate by using a water-soluble low-melting wax.CONSTITUTION: Dried powder of sucralfate is further ground to give pulverized sucralfate comprising >=90% powder having =5wt% of a water-soluble low-melting wax (e.g. polyethylene glycol). The mixture is heated the wax is melted and sucralfate particles are stuck to t...

PURPOSE: To obtain a stable sodium 14-dimethylisopropylazulene-3-sulfonate.CONSTITUTION: Sodium 14-dimethylisopropylazulene-3-sulfonate is blended with sucralfate and the blend is prepared by wet granulation method. The resultant preparation has high stability and can be preserved for a long period.COPYRIGHT: (C)1994JPO&Japio

PURPOSE: To obtain an aqueous stock suspension of sucralfate by wet pulverizing wet sucralfate powder thereby providing fine particles with hardly any dispersion in particle diameter at a low cost in short steps and including the resultant fine particles at a specific concentration.CONSTITUTION: Wet powder of sucralfate i.e. aluminum salt of sucrose polysulfate is added to water or water containing an additive and dispersed therein and the resultant dispersion is then pulverized to

PROBLEM TO BE SOLVED: To obtain the subject composition useful as a gastrointestinal medicine in which sucralfate sufficiently can adhere to mucosa in reaching a stomach sustain the antiacid action of a gastric antiacid for many hours after the adhesion and raise antitumor actions by including sucralfate and a coated gastric antiacid.SOLUTION: This composition comprises (A) sucralfate and (B) a coated gastric antiacid preferably in an amount of 500-1080 mg of the component A and 500-1400-mg of t...

PROBLEM TO BE SOLVED: To produce a liquid medicine containing a stabilized azulene derivative by performing deaerating of the liquid medicine containing the azulene derivative and substituting the head space with nitrogen.SOLUTION: This liquid medicine containing a stabilized azulene derivative is obtained by performing deaeration of the liquid medicine containing the azulene derivative to remove oxygen dissolving in the solution packing the oxygen-removed solution into a packing vessel and subs...

PROBLEM TO BE SOLVED: To avoid the suppression of absorption of medicines by using an antacid agent when sucralfate is used together with other medicines in combination.SOLUTION: An antacid is used at a weight antacid/sucralfate ratio of 1/20-2/1 preferably 1/10-1/1 to inhibit the other medicines form being adsorbed or trapped by sucralfate whereby they can maintain their intrinsic absorption properties. The antacid may be used for not only sucralfate but also other medicines or it is previously...