Disclosed are alpha-acyloxyketone derivatives which are useful as intermediates for production of N-cyano-N\'-methyl-N\'\'-[2-{(5-methyl-1H-imidazol-4-yl)methylthio}ethyl]gua nidine (common name Cimetidine; Cimetidine applies hereinafter) and Cimetidine-related compounds which have an action of controlling secretion of gastric acid and are useful as a drug for treating gastric ulcer.

N-cyano-N\'-methyl-N\'\'-(2-(5-methyl-4-imidazolylmethylthio)e hyl)guanidine (Cimetidine) which is valuable as an agent for controlling secretion of gastric acid is prepared in a high yield by reacting N-cyano-N\'-methyl-N\'\'-(2-(butane-23-dionyl)thioethyl)-guanidine as the starting compound with an ammonium salt of a carboxylic acid and formaldehyde.

Disclosed is a novel .alpha.-chloroketone derivative as a synthesis intermediate of N-cyano-N\'-methyl-N\-(2-((5-methyl-1H-imidazol-4-yl)methylthio)ethyl)guanidine (general name: Cimetidine) which shows an action of controlling the secretion of gastric acid and is valuable as a medicine for remedy of a gastric ulcer. This .alpha.-chloroketone derivative is prepared by reacting disulfide derivative with sulfuryl chloride and reacting the reaction product with methylvinyl ketone or by reacting a m...

A novel cyanoguanidine derivative represented by the following general formula (I) lt;CHEMgt; wherein X stands for a hydrogen atom a chlorine atom or a bromine atom and R stands for a lower alkyl group is an effective precursor for the synthesis of N-cyano-N'-methyl-N''-(2-(5-methyl-4-imidazolylmethylthio)ethyl)-guanidin e (Cimetidine) which has an action of controlling secretion of gastric acid and is valuable as an agent for the remedy of a gastric ulcer. This cyanoguanidine derivative is prep...

Disclosed is a novel alpha-chloroketone derivative as a synthesis intermediate of N-cyano-N\'methyl-N\'\'-(2-((5-methyl-1H-imidazol-4-yl)-methylthio) thyl)guanidine (general name Cimetidine) which shows an action of controlling the secretion of gastric acid and is valuable as a medicine for remedy of a gastric ulcer. This alpha-chloroketone derivative is prepared by reacting a disulphide derivative with sulphuryl chloride and reacting the reaction product with methylvinyl ketone or by reacting a...

Disclosed are alpha-acyloxyketone derivatives which are useful as intermediates for production of N-cyano-N\'-methyl-N\-[2-{(5-methyl-1H-imidazol-4-yl)methylthio}ethyl]guanidine (common name: Cimetidine; Cimetidine applies hereinafter) and Cimetidine-related compounds which have an action of controlling secretion of gastric acid and are useful as a drug for treating gastric ulcer."

The present invention provides a cyanoguanidine derivtive which is a precursor for the synthesis of N-cyano-N\'-methyl-N\-[2-{(5-methyl-1H-imidazol-4-yl)methylothio}ethyl]-guanidine (Cimetidine) or its relted compound which has an action of controlling secretion of acid in the stomach based on the histamine H.sub.2 receptor antagonism and is valuable as a drug for treating gastric ulcer. This cyanoguanidine derivative is prepared by reacting a haloketone derivative with an ammonium salt and a lo...

The present invention provides a cyanoguanidine derivative which is a precursor for the synthesis of N-cyano-N\'-methyl-N\-[2-{(5-methyl-1H-imidazol-4-yl)methylthio}ethyl]-guanidine (Cimetidine) or its related compound which has an action of controlling secretion of acid in the stomach based on the histamine H.sub.2 receptor antagonism and is valuable as a drug for treating gastric ulcer. This cyanoguanidine derivative is prepared by reacting other cyanoguanidine derivative with a halogenating a...

A novel cyanoguanidine derivative represented by the following general formula (I): ##STR1## wherein X stands for a hydrogen atom a chlorine atom or a bromine atom and R stands for a lower alkyl group is an effective precursor for the synthesis of N-cyano-N\'-methyl-N\-(2-(5-methyl-4-imidazolylmethylthio(ethyl)-guanidine (Cimetidine) which has an action of controlling secretion of gastric acid and is valuable as an agent for the remedy of a gastric ulcer.This cyanoguanidine derivative is prepare...

N-cyano-N\'-methyl-N\-(2-(5-methyl-4-imidazolylmethylthio)ethyl)guanidine (Cimetidine) which is valuable as an agent for controlling secretion of gastric acid is prepared in a high yield by reacting N-cyano-N\'-methyl-N\"-(2-(butane-23-dionyl)thioethyl)-guanidine as the starting compound with an ammonium salt of a carboxylic acid and formaldehyde."