The invention provides a pharmaceutical granule comprising cimetidine and 2-20% (w/w) relative to the cimetidine of a co-polymer of dimethylaminoethylmethacrylate and neutral methacrylic acid esters. Compositions of this invention have good palatability and dissolution characeristics.

PCT No. PCT/GB88/00350 Sec. 371 Date Jan. 4, 1989 Sec. 102(e) Date Jan. 4, 1989 PCT Filed May 4, 1988 PCT Pub. No. WO88/08704 PCT Pub. Date Nov. 17, 1988.The invention provides a solid pharmaceutical dosage form comprising: (i) cimetidine;and (ii) antacid, wherein at least part of the antacid is in the form of granules comprising a freely water-soluble solid diluent, the antacid, and a rapidly swellable water-insoluble disintegrant. Compositions of this type overcome the problem of the reduced b...

Chewable tablets containing unpleasant tasting medicaments such as cimetidine are provided. The palatability of the tablets is improved by including certain hygroscopic water-insoluble substances as extragranular excipients in amounts corresponding to 5% (w/w) to 15% (w/w) of the table.

11940 A PHARMACEUTICAL COMPOSITION CONTAINING CIMETIDINE The invention provides a pharmaceutical granule comprising cimetidine and 2-20% (w/w) relative to the cimetidine of a co-polymer of dimethylaminoethylmethacrylate and neutral methacrylic acid asters. Compositions of this invention have good palatability and dissolution characeristics.

A PHARMACEUTICAL COMPOSITION CONTAINING CIMETIDINE The invention provides a solid pharmaceutical dosage form comprising: (i) cimetidine: and (ii) antacid, wherein at least part of the antacid is in the form of granules comprising a freely water-soluble solid diluent, the antacid, and a rapidly swellable watar-insoluble disintegrant. Compositions of this type overcome the problem of the reduced bioavailability of cimetidine which can occur when cimetidine is co-administered with antacids.

The present invention provides a stable pharmaceutical composition suitable for oral administration comprising a suspension of particulate cimetidine in an aqueous phase, and a suspending agent, wherein substantially all of the cimetidine present is of the polymorphic B form, and optionally any other pharmaceutical excipients.

A pharmaceutical chewable tablet composition comprising: (i) granules containing a therapeutically active substance

The invention provides a solid pharmaceutical dosage form comprising: (i) cimetidine