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Gurakuso Guruupu Ltd(10)
专利信息
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[专利权人] 包含 'Gurakuso Guruupu Ltd'
[药品] 包含 'Ranitidine'
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公开号
公开日
申请号
申请日
1.
JP2954270B2
1999/9/27
JP19900090034
1990/4/4
专利标题
:Preparation of substituted ethenes
专利权人
:
Gurakuso Guruupu Ltd
;
A potassium salt useful in the production of N-substituted-1-alkylthio-2-nitroethenamines is produced by the reaction of the dipotassium salt of nitrodithioacetic acid with certain straight chain alkylamines thereby converting only one of the KS-groups to an alkylamine group.The resulting monopotassium salt may be alkylated to produce the required N-substituted-1-alkylthio compound which may be reacted with a suitable amine to produce the histamine H2-antagonist ranitidine.(From US5112995 A)
2.
JP2944678B2
1999/9/6
JP19890117167
1989/5/10
专利标题
:Drug adsorbing substance
专利权人
:
Gurakuso Guruupu Ltd
;
PURPOSE: To obtain a resin adsorbate for oral administration comprising a complex formed between ranitidine and a synthetic cation exchange resin and useful for preventing and treating gastric ulcer etc.CONSTITUTION: This resin adsorbate comprises a complex formed between ranitidine and a synthetic cation exchange resin. A synthetic cation exchange resin which is a copolymer of styrene acrylic acid or methacrylic acid and a vinyl aromatic compound is cited as the synthetic cation exchange resin ...
3.
JP2918691B2
1999/7/12
JP19930509592
1993/10/11
专利标题
:Ranichijin composition
专利权人
:
Gurakuso Guruupu Ltd
;
The present invention relates to the use of 10 to 150mg ranitidine in the treatment of minor conditions where there is an advantage in lowering gastric acidity.(From EP0788789 A1)
4.
JP2915021B2
1999/7/5
JP19890278294
1989/10/25
专利标题
:Carboxylic acid derivative
专利权人
:
Gurakuso Guruupu Ltd
;
NEW MATERIAL: The salt of a basic histamine H(sub 2)-receptor antagonist (excluding ranitidine) with a bismuth-carboxylic acid complex and its solvate.EXAMPLE: N-Cyano-N'-methyl-N"[2-[[5-methyl-1H-imidazol-4-yl) methyl]ethyl]guanidine2-hydroxy-123-propane tricarboxylate.bismuth (3(sup +) complex.USE: A medicine for treating digestive ulcer gastritis non-ulcerous dyspepsia etc.PREPARATION: This material is obtained by reacting a H(sub 2)-receptor antagonist with a proper bismuth-carboxylic acid c...
5.
JPH02256623A
1990/10/17
JP19890278294
1989/10/25
专利标题
:Carboxylic acid derivative
专利权人
:
Gurakuso Guruupu Ltd
;
NEW MATERIAL: The salt of a basic histamine H(sub 2)-receptor antagonist (excluding ranitidine) with a bismuth-carboxylic acid complex and its solvate.EXAMPLE: N-Cyano-N'-methyl-N"[2-[[5-methyl-1H-imidazol-4-yl) methyl]ethyl]guanidine2-hydroxy-123-propane tricarboxylate.bismuth (3(sup +) complex.USE: A medicine for treating digestive ulcer gastritis non-ulcerous dyspepsia etc.PREPARATION: This material is obtained by reacting a H(sub 2)-receptor antagonist with a proper bismuth-carboxylic acid c...
6.
JPH02111719A
1990/4/24
JP19890117167
1989/5/10
专利标题
:Drug adsorbing substance
专利权人
:
Gurakuso Guruupu Ltd
;
PURPOSE: To obtain a resin adsorbate for oral administration comprising a complex formed between ranitidine and a synthetic cation exchange resin and useful for preventing and treating gastric ulcer etc. CONSTITUTION: This resin adsorbate comprises a complex formed between ranitidine and a synthetic cation exchange resin. A synthetic cation exchange resin which is a copolymer of styrene acrylic acid or methacrylic acid and a vinyl aromatic compound is cited as the synthetic cation exchange resin...
7.
JPS5865215A
1983/4/18
JP19820153791
1982/9/3
专利标题
:Medicinal composition
专利权人
:
Gurakuso Guruupu Ltd
;
Pharmaceutical compositions which contain a systemic steroid-free antiinflammatory agent together with the histamine H2 antagonist ranitidine or a physiologically suitable salt thereof are described.The histamine H2 antagonist reduces damage to the gastric mucosa caused by the antiinflammatory agent.(From FR2512342 A1)
8.
JPS57154180A
1982/9/22
JP19820026720
1982/2/20
专利标题
:Manufacture of furan derivatives
专利权人
:
Gurakuso Guruupu Ltd
;
Ranitidine is prepared by reacting a compound of formula (II) (II) with aziridine.The reaction may be carried out in the absence of a solvent or preferably in the presence of a solvent such as water or an alkanol at elevated temperature.(From US4399293 A)
9.
JPS57134476A
1982/8/19
JP19810216183
1981/12/30
专利标题
:Manufacture of furan derivatives
专利权人
:
Gurakuso Guruupu Ltd
;
Ranitidine is prepared by reaction of a compound of formula (II) where L is a leaving group e.g. -SR (where R is a straight or branched C1-6 alkyl group optionally substituted by phenyl) with nitromethane at an elevated temperature e.g. 80 - 110 DEG C.(From EP0055626 A1)
10.
JPS57134475A
1982/8/19
JP19810216182
1981/12/30
专利标题
:Manufacture of furan derivatives
专利权人
:
Gurakuso Guruupu Ltd
;
Ranitidine is prepared by treating an aldehyde of formula (II) (II) with dimethylamine and a reducing agent which is capable of effecting reductive alkylation to introduce the group Me2NCH2- but which does not reduce the nitroethene group.The reaction is carried out in a suitable solvent preferably in the presence of an acid or followed by treatment with an acid.Suitable reducing agents include diborane aluminium hydride and alkali or alkaline earth metal borohydrides.The aldehyde (II) may be ...
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