专利信息

1. JP2708715B2	1998/2/4	JP19940196865	1994/8/22
专利标题：Production of morphologically homogeneous thiazole derivative 专利权人：Richter Gedeon V G Rt; The invention relates to two morphologically homogeneous forms of famotidine [N-sulfamoyl-3-(2-guanidino-thiazole-4-yl-methylthio)-propionamidine].Said forms are prepared by selective crystallisation or precipitation.(From EP0256747 A1)

2. JP2644234B2	1997/8/25	JP19870193855	1987/8/4
专利标题：Manufacture of morphologically homogeneous thiazole derivative 专利权人：Richter Gedeon V G Rt; The invention relates to two morphologically homogeneous forms of famotidine [N-sulfamoyl-3-(2-guanidino-thiazole-4-yl-methylthio)-propionamidine].Said forms are prepared by selective crystallisation or precipitation.(From EP0256747 A1)

3. JPH07316141A	1995/12/5	JP19940196865	1994/8/22
专利标题：Production of morphologically homogeneous thiazole derivative 专利权人：Richter Gedeon V G Rt; The invention relates to two morphologically homogeneous forms of famotidine [N-sulfamoyl-3-(2-guanidino-thiazole-4-yl-methylthio)-propionamidine].Said forms are prepared by selective crystallisation or precipitation.(From EP0256747 A1)

4. JPS6399065A	1988/4/30	JP19870193855	1987/8/4
专利标题：Manufacture of morphologically homogeneous thiazole derivative 专利权人：Richter Gedeon V G Rt; The invention relates to two morphologically homogeneous forms of famotidine [N-sulfamoyl-3-(2-guanidino-thiazole-4-yl-methylthio)-propionamidine].Said forms are prepared by selective crystallisation or precipitation.(From EP0256747 A1)

5. JPS6296481A	1987/5/2	JP19860211792	1986/9/10
专利标题：Manufacture of n-sulfamyl-3- (2-guanidino-thiazole-4-yl-methylthio)-propioneamidine 专利权人：Richter Gedeon V G Rt; The invention relates to a new process for the preparation of N-sulfamyl-3-(2-guanidinothiazol-4-yl-methylthio)-propionitrile (famotidine) of the formula (I) (I) by S-alkylation of 2-guanidino-thiazol-4-yl-methanethiol obtained from S-(2-guanidino-thiazol-4-yl-methyl)-isothiourea dihydrochloride of the formula (III) (III) by in situ treatment with a base which comprises carrying out S-alkylation with a N-sulfamyl-3-halopropionamidine of the formula (II) (II) wherein X stands for ...

6. JPS6261966A	1987/3/18	JP19860210816	1986/9/9
专利标题：Propionamidine derivatives and manufacture 专利权人：Richter Gedeon V G Rt; Propionamidine derivatives of the formula (I) wherein X is halogen are useful intermediates in the preparation of famotidine an anti-ulcer agent.(From EP0215639 A2)

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!	专利类型	发明实用新型外观设计
!	公开号			CN1234
!	申请号			CN1234
!	专利标题		扩展	PHARMA
!	专利权人		扩展	pfizer
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!	申请日			yyyymmdd
!	公开日			yyyymmdd
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!	摘要		扩展	PHARMA
	IPC			A01B

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