The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant antibacterial activity. The methods disclosed herein utilize reactive tetracycline-based precursor compounds reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention a substituted tetracyc...

The present invention pertains to novel 9-substituted minocycline compounds of the general formula I wherein the substituents in the general formula I have specific meanings. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states such as bacterial infections and neoplasms as well as other known applications for minocycline and tetracycline compounds in general such as blocking tetracycline efflux and modulation of gene expression.

The present invention pertains at least in part to novel 7-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states such as bacterial infections and neoplasms as well as other known applications for minocycline and tetracycline compounds in general such as blocking tetracycline efflux and modulation of gene expression.

The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant antibacterial activity. The methods disclosed herein utilize reactive tetracycline-based precursor compounds reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention a substituted tetracyc...

The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant antibacterial activity. The methods disclosed herein utilize reactive tetracycline-based precursor compounds reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention a substituted tetracyc...

PROBLEM TO BE SOLVED: To provide 7-substituted tetracycline compounds used for treatment of numerous tetracycline compound-responsive states such as bacterial infections and neoplasms as well as for other known applications for minocycline and tetracycline compounds in general such as blocking tetracycline efflux and modulation of gene expression. SOLUTION: There are provided the 7-substituted tetracycline compounds for example represented by the formula in Fig. COPYRIGHT: (C)2012JPO&INPIT...

The present invention pertains at least in part to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsible states such as bacterial infections and neoplasms as well as other known applications for minocycline and tetracycline compounds in general such as blocking tetracycline compounds in general such as blocking tetracycline efflux and modulation of gene expression.

The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant antibacterial activity. The methods disclosed herein utilize reactive tetracycline-based precursor 5 compounds reactive organic substituent precursors and transition metal catalysts under conditions such that a tetracycline compound substituted with the desired organic substituent is formed. In one embodiment of the invention a substituted tetrac...