Stable cosmetically acceptable gel formulations of the tetracycline antibiotics for the topical treatment of acne in humans. Minocycline hydrochloride is the preferred antibiotic and the pharmaceutical vehicle is a volatile silicone solvent in combination with an emollient ester cosolvent and a polyethylene gelling agent.

This disclosure describes a process for the recovery of 7-dimethylamino-6-demethyl-6-deoxytetracycline from an aqueous solution thereof by means of a calcium chloride complex of 7-dimethylamino-6-demethyl-6-deoxy-tetracycline hydrochloride.

1217936. Inorganic acid salts of sulphonamides. AMERICAN CYANAMID CO. 10 June 1968 [20 July 1967] No. 27535/68. Heading C2C. [Also in Division A5] Novel stable solid crystalline water-soluble hydrochloric and sulphuric acid salts (includes bisulphate sulphate and disulphate salts) of sulphamethazine sulphaethoxypyridazine sulphamethoxypyridazine sulphamerazine and sulphathiazole are obtained by a process which comprises forming a mixture of the sulphonamide and HCl or H 2 SO 4 dissolved in a po...

1206439. 7 - Bis - substituted hydrazino tetracyclines. AMERICAN CYANAMID CO. 15 Dec. 1967 [10 Jan. 1967; 3 March 1967] No. 57186/67. Heading C2A. The invention comprises 7-[bis-substituted hydrazino] tetracyclines of formulµ wherein R is C 1 -C 6 alkoxy phenyl C 1 -C 6 alkoxy phenoxy amino C 1 -C 6 alkylamino phenyl C 1 -C 6 alkylamino or anilino; R 1 is H alpha-CH3 or beta-CH 3 ; R 2 is H or beta OH with the proviso that when R 1 is beta-CH 3 then R 2 is H; R 1 and R 2 taken toge...

1134598. Tetracycline compositions. AMERICAN CYANAMID CO. 2 June 1967 [21 June 1966] No. 25701/67. Heading A5B. A liquid composition of a tetracycline antibiotic comprises a therapeutically effective concentration of an antibiotic of the formula wherein R 1 = H or Cl R 2 = H or OH and R 3 = H or CH 3 (With the priviso that when R 1 = Cl R 2 = OH) and glyceraldehyde and/or a compound releasing glyceraldehyde. The glyceraldehyde is suitably added as the dimer or bisulphite addition salt. The...