¿ Un método de preparación de una micropartícula homogénea de metoprolol comprendiendo el método proporcionar un medio líquido de granulación que comprende un contenido sólido de metoprolol; pulverizar el medio líquido de granulación en un lecho fluidizado; y seleccionar una micropartícula que tiene una distribución de tamaños menor que 250 µm obteniendo con ello una micropartícula homogénea seca que tiene al menos 80% en peso de metoprolol.

A method for the preparation of homogenous microparticles containing metoprolol by a fluidized bed process. The microparticles have a size distribution of less than 250 µm and contain at least 80% by weight of metoprolol.

A method of preparing a homogeneous microparticle of metoprolol the method comprising: providing a granulation liquid medium comprising a solid content of metoprolol

In the case of a multiple gear gearbox the loose gear of one of two immediately adjacent permanently engaged gear pairs is supported on the axially extended hub of the loose gear of the other gear pair and carries its shift dogs on the end face remote from the latter loose gear. Its shift dogs are arranged on the free end of the extended hub. In order to permit the transmission of high torques by means of a simple design with few components a small overall axial length and high reliability an ax...