This invention relates to modulation of the 7 nicotinic acetylcholine receptor (nAChR) by a compound of formula (I) or a salt thereof.

The present invention relates to novel piperazine compounds; to pharmaceutical compositions containing the compounds; and to the use of the compounds in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial and to treat diseases for which blocking the Cav2.2 and Cav3.2 calcium channels is beneficial e.g. to treat pain.

A method of treating or preventing diseases or conditions mediated through the action of oxytocin which comprises administering to a human in need thereof of an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof.

Compounds of formula (1) wherein R1 is 2-indanyl R2 is 1-methylpropyl R3 is 2-methyl-13-oxazol-4-yl and R4 and R5 together with the nitrogen atom to which they are attached represents morpholino process for their preparation pharmaceutical compositions containing them and their use in medicine.

The present invention relates to 1-(1-methylethyl)-4-{[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}piperazine or a pharmaceutically acceptable salt thereof in particular the hydrochloride salt thereof and crystalline forms of the hydrochloride salt; to processes for the preparation of the compound or its salt; to compositions containing it; and to its use in the treatment or prophylaxis of neurological or psychiatric diseases such as cognitive impairment fatigue or a sleep disorder for exampl...

The present invention relates to method for the treatment of allergic rhinitis comprising: administrating to a patient in need thereof a pharmaceutical formulation comprising a compound for formula (I) or a salt thereof and an anti-inflammatory glucocorticoid compound of formula (II) or a solvate thereof.

Compounds of formula (1) wherein R1 is 2-indanyl R2 is 1-methylpropyl R3 is 2-methyl-13-oxazol-4-yl and R4 and R5 together with the nitrogen atom to which they are attached represents morpholino process for their preparation pharmaceutical compositions containing them and their use in medicine.

Novel pharmaceutical formulations of a beta-2 agonist for inhaled administration via the nose or mouth and methods of using them are provided.

Compounds of formula (1) wherein R1 is 2-indanyl R2 is 1-methylpropyl R3 is 2-methyl-13-oxazol-4-yl and R4 and R5 together with the notrogen atom to which they are attached represents morpholino process for their preparation pharmaceutical compositions containing them and their use in medicine.