A combination of a 4-anilino-3-cyanoquinoline compound (e.g. HKI-272 SKI-606 EKB-569) and a capecitabine compound in the treatment of a neoplasm is provided. Regimens kits and methods for treatment of neoplasm including breast cancer including metastatic breast cancer and lung cancer using this combination optionally in combination with other anti-neoplastic agents or immune modulators are also described.

Crystalline solid forms of tigecycline Form I Form II Form III Form IV and Form V compositions comprising these crystalline solid forms and processes for preparing these crystalline solid forms are described herein.

Thioamide compounds and specifically thioamide pyrrole compounds of formula (I) wherein R1-R5 and Q are defined herein and preparation thereof are provided. These thioamide compounds can be used as progesterone receptor modulators in contraception and in the treatment of progesterone-related maladies. (see formula I)

The present invention provides compounds of formula (I) and compositions thereof methods of making them and methods of using them to modulate alpha7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders diseases and conditions. Provided compounds can affect among other things neurological psychiatric and/or inflammatory system.

Pantoprazole sodium multiparticulates are described which avoid sticking to nasogastric and gastronomy tubes. The pantoprazole multiparticulates have a spheroid core of pantoprazole or an enantiomer thereof or a salt thereof a surfactant and a distintegrant; a sub coat which is comprised of hydroxypropyl methylcellulose (hypromellose) and water an enteric coat on the sub-coat and a final seal coat over the enteric coat which is composed of hydroxypropyl methylcellulose (hypromellose) and water.

The present invention relates to novel tigecycline compositions with improved stability in both solid and solution states and processes for making these compositions. These compositions comprise tigecycline a suitable carbohydrate and an acid or buffer.

A METHOD OF TREATING GASTROESOPHAGEAL REFLUX DISEASE (GERD) ULCERS OF THE STOMACH OR DUODENUM OR ZOLLINGER-ELLISON SYNDROME IN A HUMAN BY ADMINISTERING PANTOPRAZOLE SODIUM MULTIPARTICULATES IS DESCRIBED. THE PANTOPRAZOLE MULTIPARTICULATES HAVE A SPHEROID CORE OF PANTOPRAZOLE OR AN ENANTIOMER THEREOF OR A SALT THEREOF A SURFACTANT AND A DISINTEGRANT; A SUB COAT WHICH IS COMPRISED OF HYDROXYPROPYL METHYLCELLULOSE (HYPROMELLOSE) AND WATER AN ENTERIC COAT ON THE SUBCOAT AND A FINAL SEAL COAT OVER TH...

THIS INVENTION PROVIDES COMPOUNDS OF THE FORMULA: WHEREIN A" X AND Y ARE DEFINED IN THE SPECIFICATION. THESE COMPOUNDS ARE USEFUL AS ANTIBACTERIAL AGENTS.

Progesterone receptor modulators of formula (I) or a pharmaceutically acceptable salt thereof Formula (I); wherein R R R R R R and R are as defined herein are useful for contraception and hormone replacement therapy are described. Also provided are products containing these compounds.