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LES LABORATOIRES SERVIER(1233)
MEZEI TIBOR(1)
PORCS-MAKKAY MARTA(1)
SIMIG GYULA(1)
专利信息
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1233
条记录, 当前第3/124页。
公开号
公开日
申请号
申请日
1.
US8524949B2
2013/9/3
US13/138511
2010/2/26
专利标题
:Agomelatine hydrohalide complex and preparation method thereof
专利权人
:
LES LABORATOIRES SERVIER
;
The present invention relates to a complex of agomelatine and to preparation thereof. The hydrogen halide complex of agomelatine obtained through the present method is more soluble more stable and of higher purity than agomelatine itself making it more suitable to be used in pharmaceutical preparation. Using this method product of high purity can be obtained through a simple process without having to incur further complicated steps.
2.
AU2011264206B2
2013/8/15
AU20110264206
2011/6/8
专利标题
:Agomelatine intermediates and preparation method thereof
专利权人
:
LES LABORATOIRES SERVIER
;
Intermediate compounds for preparation of agomelatine and preparation methods thereof are provided. Also provided are two novel intermediate compounds. The method is simple to manipulate well-controlled suitable for industrial production and has a high purity without complicated operations such as rectification and column chromatography separation. Meanwhile preparation methods of the two new intermediates themselves are simple and have a high yield.
3.
WO2012113999A8
2013/8/1
WO2012FR00005
2012/1/4
专利标题
:Process and intermediates for synthesizing agomelatine
专利权人
:
LES LABORATOIRES SERVIER
;
A process for the industrial synthesis of the compound of formula (I) from the allyl cyanide of formula (II) and a compound of formula (III) wherein Xa is an -S-C(S)-OR group in which R is a linear or branched (C.sub.1-C.sub.6) alkyl group.
4.
AP201307022D0
2013/7/31
AP20130007022
2012/1/4
专利标题
:New process for the synthesis of agomelatine
专利权人
:
LES LABORATOIRES SERVIER
;
5.
AP201307024D0
2013/7/31
AP20130007024
2012/1/4
专利标题
:New process for the synthesis of agomelatine
专利权人
:
LES LABORATOIRES SERVIER
;
6.
CA2610638C
2013/7/30
CA20072610638
2007/11/23
专利标题
:Use of agomelatine to obtain drugs intended for the treatment of smith-magenis syndrome
专利权人
:
LES LABORATOIRES SERVIER
;
7.
FR2985511A1
2013/7/12
FR20120000033
2012/1/5
专利标题
:Forme cristalline delta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
专利权人
:
LES LABORATOIRES SERVIER
;
Delta crystalline form of perindopril L-arginine salt (I) having X-ray powder diffraction peaks measured using a diffractometer with a copper anticathode and expressed in terms of Bragg's angle 2 theta values as given in the specification is new. Independent claims are included for: (1) the preparation of delta crystalline form of (I); and (2) a composition comprising an active agent and the delta crystalline form of (I) in combination with carriers. ACTIVITY : Cardiovascular-Gen; Hypotensive; C...
8.
FR2985512A1
2013/7/12
专利标题
:Procede de preparation du sel de l-arginine du perindopril
专利权人
:
LES LABORATOIRES SERVIER
;
Procédé de préparation du composé de formule (I) :
9.
US20130178635A1
2013/7/11
US13/733353
2013/1/3
专利标题
:Process for the preparation of the l-arginine salt of perindopril
专利权人
:
LES LABORATOIRES SERVIER
;
Process for the preparation of the compound of formula (I):
10.
US20130178464A1
2013/7/11
US13/733339
2013/1/3
专利标题
:Delta crystalline form of the arginine salt of perindopril, a process for its preparation, and pharmaceutical compositions containing it
专利权人
:
LES LABORATOIRES SERVIER
;
Delta crystalline form of the compound of formula (I): characterised by its X-ray powder diffraction diagram. Medicinal products containing the same which are useful in the treatment of cardiovascular diseases.
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