The present invention provides compounds of formula (I) and compositions thereof methods of making them and methods of using them to modulate alpha7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders diseases and conditions. Provided compounds can affect among other things neurological psychiatric and/or inflammatory system.

SAIS DE SUCCINATO DE 6-METOXI-8-[4-(1-(5~FLúOR)-QUINOLIN-8-ILA-PIPERIDIN-4-ILA)- PIPERAZIN-1 -ILA]-QUINOLINA E FORMAS CRISTALINAS DESTES. A presente invenção refere-se a formas de sal de ácido succínico do agente de ligação 5-HT ~ 1A~ 6-metóxi-8-[4-(1-(5-flúor)-quinolin-8-iI- piperidin-4-il)-piperazin-1-iI]-quinolina bem como as formas cristalinas destas composições farmacêuticas destas e métodos de uso destas.

The present invention relates to novel tigecycline compositions with improved stability in both solid and solution states and processes for making these compositions. These compositions comprise tigecycline a suitable carbohydrate and an acid or buffer.

Methods for purifying a compound of formula I are provided wherein A B X Q and R are defined herein. The methods include mixing the compound of formula I and a. solvent; adding a base to the solvent; and precipitating purified compound of formula I.

MéTODO PARA PREPARAR UMA COMPOSIçãO DE RAPAMICINA TENDO POTêNCIA AUMENTADA é descrito um método para preparar uma composição de sirolimus com uma maior potência. O método envolve selecionar um composto de rapamicina que tem menos que 15% de impurezas de rapamicina oxidativas e hidrolíticas e formular a rapamicina selecionada com um antioxidante e excipientes opcionais.

Thioamide compounds and specifically thioamide pyrrole compounds and preparation thereof are provided. These thioamide compounds can be used as progesterone receptor modulators in contraception and in the treatment of progesterone-related maladies (formula I).

Pantoprazole sodium multiparticulates are described which avoid sticking to nasogastric and gastronomy tubes.The pantoprazole multiparticulates have a spheroid core of pantoprazole or an enantiomer thereof or a salt thereof a surfactant and a disintegrant; a sub coat which is comprised of hydroxypropyl methylcellulose (hypromellose) and water an enteric coat on the sub-coat and a final seal coat over the enteric coat which is composed of hydroxypropyl methylcellulose (hypromellose) and water.(Fr...

There is provided a new composition for treating pain-associated sleep disturbances especially shortened sleep duration comprising ibuprofen and diphenhydramine. The composition is further prepared as a bilayer tablet or caplet or alternatively as a soft gelatin capsule composition to prevent interaction between the active ingredients.

PROCESSOS PARA PREPARAR CONJUGADOS DE POLIETILENO GLICOL DE MACROLìDEOS IMUNOSSUPRESSORES UM MACROLìDEO IMUNOSSUPRESSOR PEGUILADO UMA RAPAMILCINA PEGUILADA UM EVEROLIMUS PEGUILADO UM CCI-779 PEGUILADO E UM TACROLIMUS PEGUILADO E PRODUTO. São descritos processos para preparação de rapamicinas 42-peguiladas incluindo reação de uma rapamicina com um agente de acilação na presença de uma lipase para formar uma rapamicina acuada e reação da rapamicina acuada com um derivado de metóxi-(po...