1293705 Preparation of crystalline disodium -carboxybenzylpenicillin PFIZER Ine 19 April 1971 [26 Jan 1971] 27119/71 Heading C2A A process for preparing crystalline disodium -carboxybenzylpenicillin comprises the steps of combining an aqueous solution containing 10 to 50% by weight of disodium -carboxybenzylpenicillin with n-propyl alcohol removing the major portions of the solvents by codistillation with n-propyl alcohol and separating and drying the resulting disodium -carboxybenzylpenicillin....

The total synthesis of tetracycline-type antibiotics by a multistep process beginning with 3410-trioxo-12344a99a10-octahydroanthracenes comprising: (1) an aldol condensation with a glyoxalic acid ester to give a 2-carboxymethylidene-3410-trioxo-12344a99a10-octahydroanthracene ester; (2) Michael reaction of said ester with an amine to produce a 3410-trioxo-12344a99a10-octahydroanthracene-2-( alpha -amino)acetic acid ester; (3) conversion of the triketone to the corresponding 410-diketone by (a) s...

1287312 Lubricants; fuels PFIZER Inc 6 Oct 1970 [13 Oct 1969] 47551/70 Headings C5F and C5G [Also in Division C2] Industrial petroleum products such as cutting fluids jet fuels and diesel fuels may contain 2-decarboxamido-2-iminotetracyclines and substituted tetracyclines derived therefrom (see Division C2) in order to prevent antimicrobial deterioration.

1275345 Salts of -carboxybenzylpenicillin PFIZER Inc 14 April 1970 [30 Dec 1969] 17817/70 Heading C2A Crystalline mono-sodium or mono-potassium -carboxybenzylpenicillinate is prepared by extracting an aqueous solution containing 5-40% by weight of -carboxybenzylpenicillin with nbutanol n-amyl alcohol isoamyl alcohol methyl ethyl ketone or methyl isobutyl ketone at pH 2-3À5 separating the organic layer and adding thereto at least an equivalent amount of sodium or potassium lactate as aqueous solu...

1261648. Crystalline alkali metal salts of - carboxybenzyl-penicillin; penicillins and phenyl malonic acid derivatives. PFIZER Inc. 10 April 1969 [17 Oct. 1968; 4 March 1969] No. 18574/69. Headings C2A and C2C. Crystalline alkali metal salts of -carboxybenzyl-penicillin are prepared by admixing a solution of -carboxybenzylpenicillin (in a solvent selected from ethyl acetate n-butanol methylethyl ketone or methyl isobutylketone; the solution containing from 3 to 20% by weight of water) with an al...