This invention relates to nicotinamide derivatives of general formula (I) in which R1 Z and R2 have the meanings defined herein and to processes for the preparation of intermediates used in the preparation of compositions containing and the uses of such derivatives.

The invention provides methods of treating cancer using a compound of formula (1) or a pharmaceutically acceptable salt thereof particularly a malate salt in combination with various additional therapeutic agents. The invention also provides therapeutic dosing regimens using the compound of formula (1) and an additional therapeutic agent.

The present invention is related to an oral dosage form comprising an effective amount of an alkalizing agent and an azithromycin multiparticulate wherein said multiparticulate comprises azithromycin a glyceride which comprises glyceryl monobehenate glyceryl dibehenate glyceryl tribehenate or a mixture thereof and a poloxamer. Typically the oral dosage form includes any suitable oral dosing means such as a powder for oral suspension a unit dose packet or sachet a tablet or a capsule.

The invention provides methods of treating cancer using a compound of formula (1) or a pharmaceutically acceptable salt thereof particularly a malate salt in combination with various additional therapeutic agents. The invention also provides therapeutic dosing regimens using the compound of formula (1) and an additional therapeutic agent.