The present invention relates to novel piperazine compounds; to pharmaceutical compositions containing the compounds; and to the use of the compounds in therapy to treat diseases for which blocking the Cav2.2 calcium channels is beneficial and to treat diseases for which blocking the Cav2.2 and Cav3.2 calcium channels is beneficial e.g. to treat pain.

Compounds of formula (I) wherein R1 is 2-indanyl R2 is 1-methylpropyl R3 is a group selected from 2 6-dimethyl-3-pyridyl or 46-dimethyl-3-pyridyl R4 represents methyl and R5 represents hydrogen or methyl or R4 and R5 together with the nitrogen atom to which they are attached represent morpholino and pharmaceutically acceptable derivatives thereof are described as are processes for their preparation pharmaceutical compositions containing them and their use in medicine particularly their use as ox...

A method of treating or preventing diseases or conditions mediated through the action of oxytocin which comprises administering to a human in need thereof of an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof.

Compounds of formula (1) wherein R1 is 2-indanyl R2 is 1-methylpropyl R3 is 2-methyl-13-oxazol-4-yl and R4 and R5 together with the nitrogen atom to which they are attached represents morpholino process for their preparation pharmaceutical compositions containing them and their use in medicine.

The present invention relates to 1-(1-methylethyl)-4-{[4-(tetrahydro-2H-pyran-4-yloxy)phenyl]carbonyl}piperazine or a pharmaceutically acceptable salt thereof in particular the hydrochloride salt thereof and crystalline forms of the hydrochloride salt; to processes for the preparation of the compound or its salt; to compositions containing it; and to its use in the treatment or prophylaxis of neurological or psychiatric diseases such as cognitive impairment fatigue or a sleep disorder for exampl...

Disclosed herein is novel process for preparation of atovaquone which process includes reacting1H-2-benzopyran-14(3H)-dione with 4-(4-chlorophenyl)cyclohexanecarbaldehyde. The invention further discloses novel intermediates useful in the preparation of atovaquone.

A succinic acid salt 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2- (8-hydroxy-2-oxo-12-dihydroquinolin-5-yl)ethylamino]methyl}-5-methoxyphenyIcarbamoyl)ethyl]piperidin-4-yl ester biphenyl-2-ylcarbamic acid or a solvate thereof for use in treating pulmonary disorders.

A succinic acid salt of biphenyl-2-ylcarbamic acid 1-[2-(2-chloro-4-{[(R)-2-hydroxy-2- (8-hydroxy-2-oxo-12-dihydroquinolin-5-yl)ethylamino]methyl}-5-methoxyphenyIcarbamoyl)ethyl]piperidin-4-yl ester or a solvate thereof for use in treating pulmonary disorders.