1287796 6 - Salicylideneaminopenicillanic acid-salicylaldehyde adduct SANKYO CO Ltd 4 Nov 1969 [6 Nov 1968] 54056/69 Heading C2A Novel 6 - salicylideneaminopenicillanic acidsalicylaldehyde adduct is prepared by treating a 6-aminopenicillanic acid-containing fermentation broth at a pH between 6 and 9 with at least two moles of salicylaldehyde per mole of 6- aminopenicillanic acid. The adduct is isolated, or separated as a solution in a water-immiscible organic solvent for subsequent reaction with...

1276588 Anti-bacterial compositions DAIICHI SEIYAKU CO Ltd 3 June 1970 [4 June 1969] 26799/70 Heading ASB Anti-bacterial compositions comprise nalidixic acid and rifampicin in a weight ratio of from 0.05 to 10 of the former to 1 of the latter. The compositions may be administered orally or parenterally and may include a pharmaceutically acceptable carrier such as sodium carboxymethyl cellulose.

Microcrystals of chloramphenicol are produced by mixing a solution of chloramphenicol in a water-miscible organic solvent with a solution of polyvinylpyrrolidone in water under vigorous agitation. The water-miscible organic solvent is preferably an aliphatic alcohol or an aliphatic ketone and the polyvinylpyrrolidone suitably has a molecular weight within the range of from 10,000 to 750,000. The agitation may be performed mechanically, but preferably by means of an ultrasonic generator with ultr...

The invention comprises codeinone and morphinone derivatives, which are morphine antagonists, of the general formula:- wherein R is hydrogen or methyl and R1 is allyl or propargyl