The present invention relates to a complex of agomelatine and to preparation thereof. The hydrogen halide complex of agomelatine obtained through the present method is more soluble more stable and of higher purity than agomelatine itself making it more suitable to be used in pharmaceutical preparation. Using this method product of high purity can be obtained through a simple process without having to incur further complicated steps.

Intermediate compounds for preparation of agomelatine and preparation methods thereof are provided. Also provided are two novel intermediate compounds. The method is simple to manipulate well-controlled suitable for industrial production and has a high purity without complicated operations such as rectification and column chromatography separation. Meanwhile preparation methods of the two new intermediates themselves are simple and have a high yield.

A process for the industrial synthesis of the compound of formula (I) from the allyl cyanide of formula (II) and a compound of formula (III) wherein Xa is an -S-C(S)-OR group in which R is a linear or branched (C.sub.1-C.sub.6) alkyl group.

Delta crystalline form of perindopril L-arginine salt (I) having X-ray powder diffraction peaks measured using a diffractometer with a copper anticathode and expressed in terms of Bragg's angle 2 theta values as given in the specification is new. Independent claims are included for: (1) the preparation of delta crystalline form of (I); and (2) a composition comprising an active agent and the delta crystalline form of (I) in combination with carriers. ACTIVITY : Cardiovascular-Gen; Hypotensive; C...

Procédé de préparation du composé de formule (I) :

Process for the preparation of the compound of formula (I):

Delta crystalline form of the compound of formula (I): characterised by its X-ray powder diffraction diagram. Medicinal products containing the same which are useful in the treatment of cardiovascular diseases.